ABSTRACT
Langerhans cell histiocytosis (LCH) is a rare disease characterized by the proliferation of Langerhans cells and the destruction of local tissue. LCH large occurs in children, whilst incidence of the elderly population is extremely low, and there are few related studies. LCH lesions can involve multiple organs and systems, including bone tissue, lymph nodes, skin, liver, and spleen. However, it is rare that multiple soft tissues are implicated for eldly patients with LCH and present with soft tissue mass as the main manifestation. Here is a report on the clinical features, treatment and prognosis of an elderly LCH with multiple soft tissue masses as the main manifestation, in order to provide clinical reference.
ABSTRACT
Myeloproliferative neoplasms (MPN) are a group of clonal disorders of hematopoietic stem cells, and JAK2 V617F gene mutation is the main basis for the diagnosis of MPN. Previous studies have shown that BCR-ABL fusion gene and JAK2 V617F gene mutation are mutually exclusive in MPN patients, but in recent years, patients with a double mutation of both genes are often reported. The article synthesizes the relevant domestic and foreign literature in recent years, and reviews the BCR-ABL fusion gene and JAK2 V617F mutation double-positive MPN.
ABSTRACT
Objective To investigate the prognosis and its related factors of acute promyelocytic leukemia(APL).Methods Fifty-four patients with APL,from January 1994 to February 2005 in our hospital,were studied retrospectively.Univariate analysis of the potential factors influencing survival of these patients was carried out by comparison of the cases in same stage with chi square test and Log-Rank method.Prognostic indicators were demonstrated by CR rate,overall survival(OS)and event-free survival(EFS).Results 45 patients(83.3%)entered CR.The results showed that 1-year and 3-year OS of 54 patients were 81.5% and 73.3% respectively,1-year and 3-year EFS were 78.4% and 66.6% respectively.The estimated 5-year OS and EFS were 60.5?2.4% and 52.4?1.5% respectively.The analysis of prognostic factors showed that:Sex,age,initial WBC count,initial PLT count,marrow cellular morphology features,first induction regimen and time from induction therapy to CR were all important prognostic factors of APL.Conclusion Factors,including age