ABSTRACT
Objective To explore the clinical curative effect of neural endoscopic nasal adjustment surgical treatment for pituitary adenomas.Methods The clinical data of 176 patients with pituitary adenoma were retrospec-tively analyzed.82 patients in group A used microscopic surgery treatment,94 cases were treated by nerve endoscopic treatment(group B).The operation time,postoperative hospital stay time,the cutting rate,hormone levels,recovery rate and complications were compared between the two groups.Results In group A,the operation time,postoperative hospitalization time,the whole cut were (103.5 ±21.5)min,(7.8 ±1.1)d,78 cases,those of group B were (109.1 ±25.8)min,(5.2 ±1.0)d,91 cases,the operation time,whole cut of the two groups had no statistically significant differences(t=1 .55 1 ,χ2 =0.034,all P>0.05 ).The postoperative hospitalization time of group A was longer than that of group B,the difference was statistically significant(t=16.422,P0.05).In group A,the transient diabetes insipidus,nasal symptoms,complications were higher than those in the control group,the differences were statistically significant(χ2 =10.746,P 0.05 ).Conclusion Neural endoscopic nasal adjustment of surgical treatment of pituitary adenoma and the microscopic surgery has similar clinical curative effect,but has a lower incidence of complications and shorter postop-erative hospital stay.
ABSTRACT
This study examined the association of a common polymorphic allele (25G) of the low-density lipoprotein receptor-related protein1 (LRP1) gene with myocardial infarction (MI). The genotypes of LRP1 25CG (rs35282763) were determined in 347 MI patients and 347 age- and sex-frequency-matched controls from an unrelated Chinese Han population. Factor VIII (FVIII) levels were measured in the MI patients and controls by chromogenic assay and enzyme-linked immunosorbent assay (ELISA). The results showed that LRP1 25CG (rs35282763) genotype distribution did not differ significantly between patients (n=206 for 25CC, n=122 for 25CG) and controls (n=191 for 25CC, n=126 for 25CG; P>0.05). The 25G allele was not associated with a reduced risk of MI (P>0.05). Further stratifications for age, sex, and other cardiovascular risk factors did not affect the negative findings. It was concluded that the presence of the G allele at the 25CG (rs35282763) polymorphism of the LRP1 is not associated with a reduced risk of MI, and genotyping for LRP1 25CG (rs35282763) polymorphism is not useful in assessing the individual risk of MI.