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Objective:To evaluate the efficacy and safety of acupuncture combined with antihypertensive drugs in the treatment of essential hypertension through meta-analysis.Methods:RCTs about acupuncture combined with antihypertensive drugs in the treatment of essential hypertension were retrieved from CNKI, VIP, WANFANG, CBM, PubMed, Embase and Web of Science from the establishment of the databases to January 28, 2022. The risk and quality of literature publication bias were evaluated according to Cochrane 5.1.0 System Evaluation Manual, and relevant data were extracted. RevMan 5.4 software was used for meta-analysis.Results:A total of 36 RCTs involving 2 905 patients were included. Meta-analysis results showed that compared with antihypertensive drugs, acupuncture alone demonstrated advantages in reducing systolic blood pressure [ SMD=-0.70 (-1.05, -0.36), P<0.01], diastolic blood pressure [ SMD=-0.69(-1.06, -0.32), P<0.01], antihypertensive efficacy [ RR=1.11 (1.04, 1.19), P<0.01], symptomes efficacy [ RR=1.21 (1.11, 1.31), P<0.01] and comprehensive efficacy [ RR=1.35 (1.16, 1.57), P<0.01], without serious adverse reactions. Conclusion:Acupuncture alone has good clinical efficacy and safety in the treatment of essential hypertension, compared with antihypertensive drugs alone. However, researches with large samples and high quality are still needed to support the conclusion.
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Objective:To explore the clinical effect of Huayu-Ningkun liquid enema and external application of dreg for treating chronic pelvic inflammatory disease. Methods:A total of 106 patients with chronic pelvic inflammatory disease who met the inclusion criteria in the gynecological outpatient department of Beijing Hospital of Integrated Chinese and Western Medicine from January 2018 to December 2019 were divided into 2 groups by random number table method, with 53 patients in each group. The control group was treated with conventional western medicine therapy, and the observation group was combined with Huayu-Ningkun liquid enema and external application of drug residue on the basis of the control group. TCM symptom scores were performed before and after treatment, and the Quality of Life of patients was evaluated by Generic Quality of Life Inventory-74 (GQOLI-74). Serum CRP and TNF-α levels were detected by ELISA, and adverse reactions during treatment were recorded. Results:The total effective rate was 96.2% (51/53) in the observation group and 83.0% (44/53) in the control group, and the difference between the two groups was statistically significant ( χ2=4.970, P=0.026). After treatment, the TCM symptom scores of the observation group was significantly lower than that of the control group ( t=8.205, P<0.01). The scores of physical function, mental function, material life and social function were significantly higher than those in the control group ( t value were 7.503, 8.786, 7.798, 9.353, all Ps<0.001). After treatment, the levels of serum CRP (4.52 ± 3.46 g/L vs. 8.23 ± 3.35 g/L, t=5.608) and TNF-α (1.00 ± 0.35 μg/L vs. 1.52 ± 0.28 μg/L, t=14.551) in the observation group were significantly lower than those in the control group ( P<0.01). Conclusion:The Huayu-Ningkun liquid enema and drug residue external application combined with western medicine can relieve the symptoms, reduce the level of inflammatory cytokines, improve clinical efficacy of the patients with chronic pelvic inflammatory disease.
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Based on the investigation and analysis of industry dynamics of health maintenance Applications (APP) of Traditional Chinese Medicine (TCM),the paper designs and develops health maintenance APP of TCM,and describes its architecture,operating principle,functions,innovativeness,applicability scope,etc.
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This article was aimed to explore the method of traditional Chinese medicine (TCM) health maintenance knowledge base building. TCM health maintenance knowledge classification method was studied under the guidance of TCM health maintenance classification system to construct a special literature database to store TCM health maintenance knowledge. Based on TCM literature resources, TCM health maintenance knowledge service platform was designed and developed for the static display and dynamic query support of TCM health maintenance knowledge. The content of knowledge base will be accessed to the whole society. The results showed that the construction method can be a system arrangement and modern interpretation of TCM health maintenance knowledge, in order to support TCM health maintenance knowledge base and its update and service system. It was concluded that under the guidance of TCM theories, the construction of TCM health maintenance knowledge base will realize the health maintenance knowledge-sharing and service requirement of TCM.
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Objective To discuss the clinical features and treatment of isovaleric academia (IVA) patients,and to gain more comprehensive understanding of isovaleryl-CoA dehydrogenase(IVD) mutation in 2 siblings in order to raise awareness to prevent the occurrence of IVA.Methods The clinical history and laboratory test of 2 cases of children with IVA were carried out.The exons and neighboring introns of IVD gene of the whole family were PCR-amplified for DNA sequencing.The literature review of IVA in China was also conducted.Results Organic acid analysis of urine by GC/MS for both siblings showed extremely elevated concentrations of isovaleric glycine.For the older sibling,an acute episode of IVA caused severe metabolic stress and eventually death in the neonatal period.However,the disease was well-controlled for the younger sibling due to timely treatment and follow-up care for 2 years.The DNA sequencing of the IVD gene in the family revealed a novel c.1016G ＞ A(C339Y) heterozygous mutation in mother and both of the siblings.No IVD mutation was detected in father or in any of the 50 cases of healthy controls.According to literature review,15 cases of IVA were reported in recent 15 years in China,including neonatal onset (11 cases),acute episode (12 cases),odor of sweaty feet (12 cases),pancytopenia (9 cases),hyperammonemia (5 cases),hypocalcemia (6 cases),and 6 cases of death were reported.Additionally,5 cases that received treatment of BCAA-free formula milk showed positive outcome.However,only 2 cases were followed up for more than 2 years.Conclusions Two new IVA patients carrying c.1016G ＞ A(C339Y) mutation were reported in China.The mutation may lead to conformational change and functional deficient of the IVD protein.It is also necessary to point out that using direct DNA sequencing can not identify all patients with IVA due to limitations of this technology,and thus clinicians should be aware of the possibility of genetic misdiagnosis.Moreover,there is a trend of increasing IVA in China in recent years.
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This article discussed the library services for readers from their needs of TCM ancient literature.We believed the library service should focus on the readers needs to elevate its knowledge service ability,to establish new service mode,and to meet the TCM ancient literature needs of readers greatly.
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This survey included 59 secondary researches of traditional pharmaceutical patent literatures. The analysis was made on statistical indicator of the amount of annual papers, authors, institutions, published journals and re-search contents. The survey revealed that in the field of traditional Chinese medicine (TCM), the number of sec-ondary research of patent literature was on the increase, and the degree of concern of TCM patent was far more than others. This survey not only assisted the understanding of current condition of TCM patent literatures, but also held its development trend in order to apply it in the studies.
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Objective This study analyzes the main technical fields and their mutual correlation concerning the international patents of acupuncture to provide decision support for the strategy of developing acupuncture related products.Methods Derwent Innovation Index was applied as the data source,Thomson Data Analyzer was adopted as the main analyzing tool,and the co-occurring clustering spectrum analysis method of international patent number (IPC) was used.Results Based on the retrieval and analyzed results,the main classification of international patent of acupuncture and the technical association diagram of Chinese medicine acupuncture patents were formed.Conclusion The main technical fields of acupuncture international patent included acupuncture needles,acupuncture instruments combined with drug and acupuncture instruments combined with modem physical methods as well as the point health care products.Among them,the methods applied in acupuncture,namely the magnetic therapy method,laser therapy,thermal therapy,roller and ball massage adopted in acupuncture point massage instruments which combine traditional herbal medicine,have already been the research hotspot of current acupuncture patent products.
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In this paper,we analyze the current situation of the national standardization on acupuncture needles and related patents.Through analyzing the international research focus on the acupuncture needle patents,we give some strategic suggestions on the intellectual property protection of acupuncture needles and traditional Chinese medicine.
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To carry out research on the construction of standardized digital research platform of traditional Chinese medicine.Beginning from the consolidation of data usage resources,the strengthening of environmental construction,the improvement of quality on database creation and the perfection of training mechanism,the construction of standardized digital research platform of traditional Chinese medicine can be improved with the times,adapting to the times and meeting the demands of society.To meet the demands,the construction of digital scientific research foundation platform was perfected by improving quality and emphasizing on application.The service capabilities of standardized Chinese medical information can be promoted by establishing a new information scientific research model.
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From the perspective of efficacy evaluation based on the literatures of MEDLINE database,the study carries out a bibliometrics study on domestic and foreign acupuncture clinical trials of the past three decades.The study involves the statistical classification on different systems and diseases,as well as statistics of diseases species on RCT or non- RCT involved,which will provide ideas and directions on diseases selection for the efficacy evaluation and re-evaluation researches in the field of evidence based medicine.
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This paper describes the relationship between standards and intellectual property rights,describes the importance of putting the intellectual property protection into the International standards of Chinese medicine by the examples.According to the Chinese medicine's own characteristics and actual conditions in our country,the author points out some suggestions on how to put the intellectual property protection into the International standards of Chinese medicine.
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<p><b>OBJECTIVE</b>To study chemical constituents in the seeds of Datura Stramonium (Solanaceae family).</p><p><b>METHOD</b>Compounds were isolated and purified by silica gel, MCI and Sephadex LH-20 column chromatography, and their structures were determined based on physicochemical constants and spectroscopic analysis including NMR and MS.</p><p><b>RESULT</b>Twelve compounds were isolated and identified from Datura stramonium, they were N-trans-feruloyl tryptamine (1), hyoscyamilactol (2), scopoletin (3), umckalin (4), daturaolone (5), daturadiol (6), N-trans-ferulicacyl- tyramine (7), cleomiscosin A (8), fraxetin (9), scopolamine (10), 1-Acetyl-7-hydrox-beta-carbol-ine (11), 7-hydroxy-beta-carbolinel-propionic acid (12).</p><p><b>CONCLUSION</b>Compound 2, 7, 9 and 12 were obtained from Datura genus for the first time, whereas compound 1, 4, 8 and 11 were obtained from the Solanaceae family for the first time.</p>
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Datura stramonium , Chemistry , Seeds , ChemistryABSTRACT
Objective To explore more effective treatments of Chinese medicine for diabetic nephropathy.Methods This study took opened non-relevant documents knowledge discovery method to study the diabetic nephropathy literatures in order to find the hidden links among literatures. A valuable scientific hypothesis will be put forward upon the study to guide or implement a new knowledge discovery after it acquire the agreement of experts. Results Use keywords frequency statistics method based on open non-related literature knowledge discovery, the anti-inflammatory herbs were filtered out Most herbs with anti-inflammatory effects had the functions of clearing away heat and detoxicating, expelling wind and removing dampness. Conclusion Prescriptions with the functions of clearing away heat and detoxicating, expelling wind and removing dampness may delay the occurrence and development of diabetic nephropathy and play an important role in curing this disease.
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Objective To Analyze the distribution characteristics of Hyperthyroidism's syndrome and the relationship between symptoms and thyroid hormones. Methods The TCM syndromes of a total of 78 patients with hyperthyroidism were differentiated. The relationship between syndrome and general condition of patients (gender and age, etc.) were analyzed;correlation between symptoms and thyroid hormones were also studied. Results Of all 78 patients, patients with yin deficiency and hyperactive yang accounted for 43.6%; patients with internal disturbance of phlegm-fire accounted for 30.8 %; and patients with hypteracitivity of heart-fire and liver-fire accounted for 25.6%. The severity of all the symptoms showed positive correlation with hyroid hormones (the value of r is positive, P＜0.05); and no linear relationship with TSH (P＞0.05).Conclusion The syndrome of yin deficiency and hyperactive yangI was the most common syndrome type. Thyroid hormones had direct proportion with the severity of syndrome.
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Objective To further discuss the characteristic of diabetic nephropahty,analyze its cause and pathogenesis,and make clear the relation between symptoms and syndrome,and to provide proof for prevention and therapy of this disease.Methods Records of 200 diabetic nephropathy patients treated clinically were collected and SPSS(Statistical Package for Social Science)12.0 was applied for analyzing.According to different conditions of the renal function,We divide the cases into two groups to study the relations between symptoms and syndrome.Results 1.The common symptoms of diabetic nephropathy are heavy body and drowsiness(74%),tired and debilitation(70%),and deficient breath and unwilling to speak(64%).2.The main syndromes of diabetic nephropathy are syndrome of deficiency of Qi、syndrome of yin asthenia,syndrome of dampness-heat blocking in the middle,and syndrome of blood stasis.Conclusion According to the research,the highest frequent appearing syndromes of deficiency were syndrome of Qi deficiency and syndrome of Yin deficiency,while the syndrome of dampness-heat blocking in the middle ranked No.1 in sthema syndromes and then caine the syndrome of blood stasis.However,the syndrome of blood stasis was the most severe,and this syndrome existed from the beginning to the end of this disease.
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Objective According to the relevant literatures recorded in the CNKI bibliographic database from January 1994 to December 2007,research and application situation of exercise therapy have been investigated and analyzed.Methods Searched for"exercise therapy"in the MeSH and found 25,691 articles.In order to enhance the relevance of the literature search.limited"exercise therapy"being searched by"title search"and got 1102 articles.Results This article introduced the history and researching situation of exercise therapy,and made an investigation on the number of articles in the CNKI bibliographic database of previous 14 years and the number of articles on the top 10 diseases treated with exercise therapy.We found the largest amount of articles on exercise therapy was dealt with diabetic disease.Conclusion Exercise therapy can help to treat diseases caused by bad living habits.