Association between fatty liver and type 2 diabetes in the baseline population of Jinchang Cohort / 中华流行病学杂志

Objective To explore the association between fatty liver and type 2 diabetes mellitus (T2DM) in the baseline-population of Jinchang cohort study.Methods Data from all the participants involved in the baseline-population of Jinchang cohort study was used,to compare the risks of T2DM in fatty liver and non fatty liver groups and to explore the interaction between family history or fatty liver of diabetes and the prevalence of T2DM.Results Among all the 46 861 participants,10 574 were diagnosed as having fatty liver (22.56％),with the standardized rate as 20.66％.Another 3 818 participants were diagnosed as having T2DM (8.15％) with standardized rate as 6.90％.The prevalence of T2DM increased in parallel with the increase of age (trendx2 =2 833.671,trend P＜ 0.001).The prevalence of T2DM in the fatty liver group was significantly higher than that in the non-fatty liver group,both in men or women and in the overall population.Compared with the group of non-fatty liver,the risks of T2DM in fatty liver group were seen 1.78 times higher in males,2.33 times in women and 2.10 times in the overall population,after adjustment for factors as age,levels of education,smoking,drinking,physical exercise,BMI,family history of diabetes and some metabolic indicators (pressure,TC,TG,uric acid,ALT,AST,gamma-glutamyl transferase).Date from the interaction model showed that fatty liver and family history of diabetes present a positive additive interaction on T2DM (RERI=1.18,95％CI:0.59-1.78;AP=0.24,95％CI:0.14-0.34;S=1.43,95％CI:1.21-1.69).Conclusions Fatty liver could significantly increase the risk of T2DM and a positive additive interaction was also observed between fatty liver and family history of diabetes on T2DM.It was important to strengthen the prevention program on T2DM,in order to effectively control the development of fatty liver.

Association between fatty liver and type 2 diabetes in the baseline population of Jinchang Cohort / 中华流行病学杂志

Objective To explore the association between fatty liver and type 2 diabetes mellitus (T2DM) in the baseline-population of Jinchang cohort study.Methods Data from all the participants involved in the baseline-population of Jinchang cohort study was used,to compare the risks of T2DM in fatty liver and non fatty liver groups and to explore the interaction between family history or fatty liver of diabetes and the prevalence of T2DM.Results Among all the 46 861 participants,10 574 were diagnosed as having fatty liver (22.56％),with the standardized rate as 20.66％.Another 3 818 participants were diagnosed as having T2DM (8.15％) with standardized rate as 6.90％.The prevalence of T2DM increased in parallel with the increase of age (trendx2 =2 833.671,trend P＜ 0.001).The prevalence of T2DM in the fatty liver group was significantly higher than that in the non-fatty liver group,both in men or women and in the overall population.Compared with the group of non-fatty liver,the risks of T2DM in fatty liver group were seen 1.78 times higher in males,2.33 times in women and 2.10 times in the overall population,after adjustment for factors as age,levels of education,smoking,drinking,physical exercise,BMI,family history of diabetes and some metabolic indicators (pressure,TC,TG,uric acid,ALT,AST,gamma-glutamyl transferase).Date from the interaction model showed that fatty liver and family history of diabetes present a positive additive interaction on T2DM (RERI=1.18,95％CI:0.59-1.78;AP=0.24,95％CI:0.14-0.34;S=1.43,95％CI:1.21-1.69).Conclusions Fatty liver could significantly increase the risk of T2DM and a positive additive interaction was also observed between fatty liver and family history of diabetes on T2DM.It was important to strengthen the prevention program on T2DM,in order to effectively control the development of fatty liver.

Risk factors of gout in Jinchang cohort: a Cox regression analysis / 中华流行病学杂志

Objective To explore the incidence and risk factors of gout in Jinchang cohort and provide scientific evidence for the prevention and control of gout.Methods People without gout detected by baseline survey in Jinchang cohort were selected as study subjects.All the subjects were followed up through questionnaire interview,physical examination as well as laboratory test from January 24,2013 to November 24,2015.Cox regression model was used to analyze the risk factors for gout in Jinchang cohort.In addition,log-linear model was used to analyze the interaction between risk factors.Results A total of 33 153 subjects were followed up,and there were 277 newly diagnosed gout cases in the cohort.The overall incidence of gout was 0.8％.The incidence of gout in males was higher than that in the females,but the incidence of gout in males and females was similar after the age of 60 years.Cox regression analysis showed that age ＞40 years (at age 40 to 59 years:HR=2.982,95％CI:1.503-5.981;at age 60 to 91 years:HR=2.588,95％CI:1.107-6.049),alcohol abuse (HR=2.234,95％CI:1.128-4.427),obesity (HR=2.204,95％CI:1.216-3.997),diabetes (HR=2.725,95％CI:1.500-4.950) and high uric acid (HR=5.963,95％CI:3.577-9.943) were risk factors for gout,while weekly beans intake ≥0.25 kg (HR=0.528,95％CI:0.345-0.808) and regular physical exercise (HR=0.499,95％ CI:0.286-0.869) were protective factors for gout.The analysis with log-linear model showed that there were two order effects between the risk factors.Conclusions Age,beans intake,alcohol abuse,physical exercises,obesity,diabetes and high uric acid were important factors influencing the incidence of gout.It is important to have healthy lifestyle and dietary habits,receive regular health examination to prevent and control the incidence of gout in this cohort.

Risk factors of gout in Jinchang cohort: a Cox regression analysis / 中华流行病学杂志

Objective To explore the incidence and risk factors of gout in Jinchang cohort and provide scientific evidence for the prevention and control of gout.Methods People without gout detected by baseline survey in Jinchang cohort were selected as study subjects.All the subjects were followed up through questionnaire interview,physical examination as well as laboratory test from January 24,2013 to November 24,2015.Cox regression model was used to analyze the risk factors for gout in Jinchang cohort.In addition,log-linear model was used to analyze the interaction between risk factors.Results A total of 33 153 subjects were followed up,and there were 277 newly diagnosed gout cases in the cohort.The overall incidence of gout was 0.8％.The incidence of gout in males was higher than that in the females,but the incidence of gout in males and females was similar after the age of 60 years.Cox regression analysis showed that age ＞40 years (at age 40 to 59 years:HR=2.982,95％CI:1.503-5.981;at age 60 to 91 years:HR=2.588,95％CI:1.107-6.049),alcohol abuse (HR=2.234,95％CI:1.128-4.427),obesity (HR=2.204,95％CI:1.216-3.997),diabetes (HR=2.725,95％CI:1.500-4.950) and high uric acid (HR=5.963,95％CI:3.577-9.943) were risk factors for gout,while weekly beans intake ≥0.25 kg (HR=0.528,95％CI:0.345-0.808) and regular physical exercise (HR=0.499,95％ CI:0.286-0.869) were protective factors for gout.The analysis with log-linear model showed that there were two order effects between the risk factors.Conclusions Age,beans intake,alcohol abuse,physical exercises,obesity,diabetes and high uric acid were important factors influencing the incidence of gout.It is important to have healthy lifestyle and dietary habits,receive regular health examination to prevent and control the incidence of gout in this cohort.

Application of cohort study in cancer prevention and control / 中华流行病学杂志

Cancer control is a long-term work.Cancer research and intervention really need the support of cohort study.In the recent years,more and more cohort studies on cancer control were conducted in China along with the increased ability of scientific research in China.Since 2010,Cancer Hospital,Chinese Academy of Medical Sciences,collaborated with Lanzhou University and the Worker's Hospital of Jinchuan Group Company Limited,have carried out a large-scale cohort study on cancer,which covered a population of more than 50 000 called "Jinchang cohort".Since 2012,a National Key Public Health Project,"cancer screening in urban China",has been conducted in Jinchang,which strengthened the Jinchang cohort study.Based on the Jinchang cohort study,historical cohort study,cross-sectional study and prospective cohort study have been conducted,which would provide a lot of evidence for the cancer control in China.

Cancer burden in the Jinchang cohort / 中华流行病学杂志

<p><b>OBJECTIVE</b>To understand the disease burden caused by cancers in Jinchang cohort, and develop effective strategies for cancer prevention and control in this population.</p><p><b>METHODS</b>The cancer mortality data from 2001 to 2013 and the medical records for cancer patients from 2001 to 2010 in Jinchang cohort were collected. The disease burden caused by cancer was analyzed by using mortality rate, potential years of life lost (PYLL), working PYLL (WPYLL), and direct economic burden.</p><p><b>RESULTS</b>During 2001-2013, in Jinchang cohort, the five leading cancers ranked by mortality rate were lung cancer (78.06/100,000), gastric cancer (38.03/100,000), liver cancer (37.23/100,000), esophageal cancer (19.06/100,000), and colorectal cancer (9.53/100,000). The five leading cancers in terms of PYLL (person-years) and WPYLL (person-years) were lung cancer (3480.33, 1161.00), liver cancer (2809.03, 1475.00), gastric cancer (2120.54, 844.00), esophageal cancer (949.61, 315.00), and colorectal cancer (539.90, 246.00). From 2001 to 2010, the five leading cancers in term of average daily cost of hospitalization were gastric cancer (8,102.23 Yuan), esophageal cancer (7135.79 Yuan), colorectal cancer (7064.38 Yuan), breast cancer (6723.53 Yuan), and lung cancer (6309.39 Yuan).</p><p><b>CONCLUSIONS</b>The cancers common causing higher disease burden in Jinchang cohort were lung cancer, gastric cancer, liver cancer, esophageal cancer and colorectal cancer. The lung cancer disease burden was the highest.</p>

Disease burden of lung cancer in Jinchang cohort / 中华流行病学杂志

<p><b>OBJECTIVE</b>To understand the current status of lung cancer disease burden in Jinchang cohort.</p><p><b>METHODS</b>In this historical cohort study, the mortality data of the lung cancer from 2001 to 2013 and medical records of the lung cancer cases from 2001 to 2010 in Jinchang cohort were used, analyze mortality, direct economic burden, potential years of life lost (PYLL) and working PYLL (WPYLL) associated with lung cancer.</p><p><b>RESULTS</b>A total of 434 lung cancer deaths occurred in Jinchang cohort from 2001 to 2013. The crude mortality rate of lung cancer was 78.06 per 100,000 from 2001 to 2013, with the increasing rate of 4.77%. The mortality rate of lung cancer in males and females were about 108.90 per 100,000 and 26.08 per 100,000 with the increasing rate of 4.24% and 6.91%, respectively. During the thirteen years, the PYLL and average PYLL (APYLL) of lung cancer were 3 721.71 person-years and 8.58 years. The APYLL of lung cancer in females (15.94 years) was higher than that in males (7.87 years). The WPYLL and the average WPYLL (AWPYLL) of lung cancer were 1161.00 person-years and 2.68 years, respectively. The AWPYLL of lung cancer was also higher in females than in males. The direct economic burden of lung cancer from 2001 to 2010 in Jinchang cohort was 6309.39 Yuan per case with no increased trend.</p><p><b>CONCLUSION</b>Lung cancer is the main health problem in Jinchang cohort, causing heavy disease burden.</p>

Disease burden of gastric cancer in Jinchang cohort / 中华流行病学杂志

<p><b>OBJECTIVE</b>To understand the current status of disease burden caused by gastric cancer in Jinchang cohort.</p><p><b>METHODS</b>In this historical cohort study, the data of gastric cancer deaths from 2001 to 2013 and the medical records of gastric cancer cases from 2001 to 2010 in Jinchang cohort were collected to analyze the mortality, potential years of life lost (PYLL), working PYLL (WPYLL) associated with gastric cancer, and the medical expenditure data were used to evaluate the direct economic burden. Spearman correlation analysis and the average growth rate were used to describe the change trend of disease burden of gastric cancer.</p><p><b>RESULTS</b>A total of 213 gastric cancer deaths occurred in Jinchang cohort from 2001 to 2013. The average annual crude mortality rate of gastric cancer was 38.30 per 100,000 in Jinchang cohort during 2001-2013 and no obvious change was observed. The crude mortality rate in males was 6.84 times higher than that in females. Gastric cancer death mainly occurred in age group 50-79 years (82.62%), while the mortality rates was increasing among the people under 50 years with an average annual increase rate of 0.77%. The annual average PYLL (APYLL) and average WPYLL (AWPYLL) caused by gastric cancer decreased by 8.43% and 10.46%, respectively. No obvious change in medical expenditure of gastric cancer cases was observed in Jinchang Cohort during 2001-2010, and the medical expenditure and average daily cost of hospitalization were 8102.23 Yuan, and 463.45 Yuan per capita, respectively.</p><p><b>CONCLUSIONS</b>The burden of disease for gastric cancer was heavy in Jinchang cohort. The PYLL and WPYLL had no change, while the APYLL and AWPYLL showed a increasing trend during the last ten years. Direct economic burden of inpatients with gastric cancer had no change.</p>

Disease burden of liver cancer in Jinchang cohort / 中华流行病学杂志

<p><b>OBJECTIVE</b>To understand the current status of the disease burden of liver cancer in Jinchang cohort.</p><p><b>METHODS</b>All the liver cancer death data from 2001 to 2013 and medical records of liver cancer cases from 2001 to 2010 in Jinchang cohort were collected for the analyses of the mortality, standardized mortality, potential years of life lost (PYLL) and working PYLL (WPYLL) associated with liver cancer. Spearman correlation and the average growth rate were used to analyze the trends.</p><p><b>RESULTS</b>A total of 207 liver cancer deaths occurred in Jinchang cohort from 2001 to 2013, accounting for 16.68% of total cancer deaths. There were 259 liver cancer inpatients, accounting for 6.79% of the total cancer cases inpatients, in which 83 died (32.05%). Liver cancer death mainly occurred in males, accounting for 88.89%, and the liver cancer deaths in females accounted for 11.11%. The standardized mortality rate was 42.32/100,000 in males and 15.31/100,000 in females. The growth rate of liver cancer mortality was 5.62% from 2001 to 2013. Liver cancer deaths mainly occurred in age groups 60-69 years (26.57%) and 50-59 years (24.15%). The PYLL was 2906.76 person-years, the average PYLL was 14.04 years. The WPYLL was 1477.00 person-years and the average WPYLL was 7.14 years. The direct economic burden of liver cancer was 6270.78 Yuan per person, 301.75 Yuan per day. The average stay of hospitalization was 21.32 days.</p><p><b>CONCLUSION</b>The mortality rate of liver cancer is increasing and the disease burden is still heavy.</p>

Disease burden of colorectal cancer in Jinchang cohort / 中华流行病学杂志

<p><b>OBJECTIVE</b>To evaluate the disease burden of colorectal cancer in Jinchang cohort, and provide evidence for preventing colorectal cancer and reducing the disease burden of colorectal cancer in the cohort.</p><p><b>METHODS</b>The colorectal cancer mortality data from 2001 to 2013 and the medical records of colorectal cancer patients from 2001 to 2010 were collected for this retrospective cohort study. The colorectal cancer disease burden was described by using mortality rate, standardized mortality rate, medical expenditure, potential years of life lost (PYLL), average potential years of life lost (APYLL), working potential years of life lost (WPYLL), and average working potential years of life lost (AWPYLL). The development trend in disease burden of colorectal cancer was analyzed by using Spearman correlation and the average growth rate.</p><p><b>RESULTS</b>The crude mortality rate of colorectal cancer from 2001 to 2013 was 9.53/100,000 with the average annual growth rate of 12.89%. The PYLL, APYLL, WPYLL and AWPYLL of colorectal cancer were 485.00 person-years, 9.15 years, 253.00 person-years, and 4.77 years, respectively. The direct medical expenditure due to colorectal cancer was 7064.38 Yuan per case and 408.43 Yuan per day. There was no increasing trend in the direct medical expenditure due to colorectal cancer.</p><p><b>CONCLUSION</b>Colorectal cancer mortolity rate was on the rise and it caused heavy disease burden in Jinchang cohort.</p>