ABSTRACT
Objective To investigate the distribution and drug resistance pathogens from ventilator-associated pneumo-nia (VAP)patients for to better guide clinical treatment. Methods The medical records of 598 mechanical ventilation patients were retrospectively reviewed and the results of sputum culture and antibiotic resistance of pathogens from VAP patients were analyzed. Results The 251 strains of pathogens were isolated from lower respiratory tract sputum specimens in 221 patients with ventilator-associated pneumonia. Among them, the isolation rate of the gram-negative bacteria was the highest (71.3%),followed by the gram-positive bacteria (17.9%). The Acinetobacter baumannii and Staphylococcus were the top species in gram-negative and gram-positive bacteria, respectively. The isolation rate of the pan-resistant for Acinetobacter baumannii was 27.9% and the isolation rate of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) were 66.7% and 61.5%, respectively. Conclusion The gram-negative bacteria remain dominant in the pathogens causing VAP,and related strains are highly drug resistant. It is crucial for timely monitoring of drug resistance of the pathogens.