ABSTRACT
Objective To investigate the classification of human papilloma virus(HPV) infection in different pathological grading of cervical intraepithelial neoplasia.Methods 150 cases with cervical premalignant lesions were prospectively collected,50 cases in each mild(CINⅠ),moderate(CINⅡ) and severe(CINⅢ) cervical intraepithelial neoplasia group.HPV infection type of the three groups were detected and analyzed.And the association between different cervical intraepithelial neoplasia multiple HPV infection was analyzed as well.Results CINⅠ,Ⅱ and Ⅲ patients with HPV16 infection were 7,18 and 21 cases,respectively;the patients with HPV18 infection were 6 cases,14 cases,and 15 cases,respectively;the patients with HPV58 infection were 5 cases,13 cases and 15 cases,respectively;the patients with multiple HPV infection were 3 cases,23 cases and 29 cases,respectively.All the above differences were statistically significant(x2=10.222,6.140 and 6.527,all P<0.05).Conclusion High risk HPV16,18 and 58 are the risk factors of moderate and severe CIN,which may lead to the occurrence of cervical cancer in women.
ABSTRACT
BACKGROUD/OBEJECTIVES: Arsenic, which causes human carcinogenicity, is ubiquitous in the environment. This study was designed to evaluate modulation of arsenic induced cancer by resveratrol, a phytoalexin found in vegetal dietary sources that has antioxidant and chemopreventive properties, in arsenic trioxide (As2O3)-induced Male Wistar rats. MATERIALS/METHODS: Adult rats received 3 mg/kg As2O3 (intravenous injection, iv.) on alternate days for 4 days. Resveratrol (8 mg/kg) was administered (iv.) 1 h before As2O3 treatment. The plasma and homogenization enzymes associated with oxidative stress of rat kidneys were measured, the kidneys were examined histologically and trace element contents were assessed. RESULTS: Rats treated with As2O3 had significantly higher oxidative stress and kidney arsenic accumulation; however, pretreatment with resveratrol reversed these changes. In addition, prior to treatment with resveratrol resulted in lower blood urea nitrogen, creatinine and insignificant renal tubular epithelial cell necrosis. Furthermore, the presence of resveratrol preserved the selenium content (0.805 +/- 0.059 microg/g) of kidneys in rats treated with As2O3. However, resveratrol had no effect on zinc level in the kidney relative to As2O3-treated groups. CONCLUSIONS: Our data show that supplementation with resveratrol alleviated nephrotoxicity by improving antioxidant capacity and arsenic efflux. These findings suggest that resveratrol has the potential to protect against kidney damage in populations exposed to arsenic.