ABSTRACT
Objective To investigate the effects from head angle and locking times of locking screws on mechanical properties of the screw-plate system, so as to provide a theoretical basis for doctors to select appropriate locking screws and master the locking times in clinical surgical procedure. Methods Locking screws with different head angles were selected to match with locking compression plates in the case of different locking times, and cantilever bending method was used to compare the differences of mechanical properties in each group. Results There were significant differences in failure load and bending stiffness between locking compression plate and locking screw with different head angles (P0-05). The failure modes of locking screw with different head angles and different locking times were different, and the failure mode of locking screw had a positive correlation with its head angle and locking times. Conclusions The differences in mechanical properties between locking screw with different head angles and locking compression plate cannot be neglected. It is suggested that doctors should choose locking screw and locking compression plate with the best locking degree in clinical procedure, and choose the right torque wrench to lock in multiple times if necessary, thus to prevent screw loosening from affecting recovery of the patients.
ABSTRACT
Objective To explore the expression and its significance of Notch1、Notch2、Notch3 transmembrane receptor protein in different types of lymphoma tissues. Methods By employing immunohistochenistry SP staining,the expres-sions of Notch in 59 lymphomas were detected, and 21 cases of lymph-node reactive hyperplasia served as control group. Results The expression of Notch1 was significantly higher in T-cell lymphoma and NK/T-cell lymphoma than that in the B-cell lymphoma and the control group, the difference was statistically significant (P<0.01). The expres-sion of Notch2 was obviously higher in B-cell lymphoma and NK/T-cell lymphoma than that in the T-cell lymphoma and the control group,the difference was statistically significant(P<0.01). The expression of Notch3 in NK/T-cell lym-phoma group was significantly higher than that in the other three groups,the difference was statistically significant (P<0.01). Conclusion Abnormal activation of Notch signaling pathway is closely related to the occurrence and develop-ment of lymphoma. The occurrence and development of NK/T-cell lymphoma is probably associated with the high ex-pression of Notch1, Notch2 and Notch3; The occurrence and development of T- cell lymphoma is probably related to the high expression of Notch1; The occurrence and development of B-cell lymphoma is probably associated with the high expression of Notch2.