Expression and significance of PCNA,VEGF and MVD in esophageal squamous cell carcinoma / 中国基层医药

Objective To investigate the expression of proliferating cell nuclear antigen(PCNA),vascular endothelial growth factor(VEGF) and microvessel density(MVD) in squamous cell carcinoma;and to explore the relationship between their expression and tumor biological behavior.Methods The expressions of PCNA,VEGF and MVD were analyzed by immunohistochemical method in 71 cases of esophageal squamous cell carcinoma.Results The intensity positive rate of PCNA indicated close relationship between cell differentiation and lymph node metastasis(P