ABSTRACT
Objective To examine the situation of iodine nutritional status and the prevalence of hypothyroidism in Pinggu District of Beijing City,and analyze the illness-related factors.Methods A cross-sectional survey was performed in 734 adults who had lived more than five years in Pinggu District,a random urine sample was collected in the morning from each adult,urine iodine was tested via the arsenic cerium catalytic spectrophotometry method (WS/T 107-2006);edible salt samples were collected,salt iodine was tested via the method of direct titration (GB/T 13025.7-1999);fasting blood samples were collected,electrochemiluminescence was used to measure three free triiodothyronine (FT3),free thyroid hormone (FT4),thyroid-stimulating hormone (TSH),thyroglobulin antibodies (TgAb) and thyroid peroxidase antibody (TPOAb);automatic biochemical analyzer was used to measure triglyceride (TG);high pressure liquid phase method was used to measure glycosylated hemoglobin (HbAlc).The results of routine physical examination,thyroid examination by color Doppler ultrasound and questionnaires were collected.Results A total of 696 urine samples were collected,the median of urine iodine was 125.25 μg/L,and the values of male (287 cases) and female (409 cases) were 125.19 and 125.79 μg/L,respectively.Forty-nine non-iodized salt samples (6.7％),647 qualified iodized salt samples (88.1％),and 38 unqualified iodized salt samples were detected (5.2％),respectively.Subclinical hypothyroidism (58 cases,89.2％) in all hypothyroidism (65 cases) was the most common hypothyroidism.Independent risk factors for hypothyroidism of male were increased TG [odds ratio (OR) =3.298,95％ confidence interval (CI):1.112-9.785]and over 60 years old (OR =8.657,95％CI:1.015-73.863);independent risk factors for hypothyroidism of female were physical work (OR =3576,95％CI:1.323-9.670),increased TgAb (OR =2.306,95％CI:1.099-4.841) and diffused change of thyroid (OR =5.177,95％CI:1.944-13.787).Conclusions The iodine nutritional status of residents in Pinggu District of Beijing City is good.Main type of hypothyroidism is subclinical hypothyroidism.Age,diffused change of thyroid,etc.are the influencing factors of hypothyroidism.
ABSTRACT
Objective: To measure serum testosterone level, plasma levels of interleukin-18 (IL-18) and IL-10 and explore their correlation in patients with different types of coronary heart disease (CHD), and their possible role in occurrence and development of CHD. Methods: A total of 96 male CHD patients were divided into acute myocardial infarction (AMI) group (n=35), unstable angina pectoris (UAP) group (n=32) and stable angina pectoris (SAP) group (n=29). Another 30 patients who were excluded for CHD by coronary angiography were enrolled as non CHD control group. Enzyme linked immunosorbent assay (ELISA) was used to measure serum testosterone level and plasma levels of IL-18 and IL-10 in all groups. Results: Compared with non CHD control group, there were significant decreases in serum testosterone level [(13.46±1.99) mmol/L vs. (6.89±1.35) mmol/L vs. (5.02±1.87) mmol/L, t=1.917～2.365, P<0.05 both] in UAP group and AMI group, and that of AMI group was significantly lower than that of UAP group, t=1.034, P<0.05; there were significant increases in IL-18 levels [(146.72±79.36) pg/ml vs. (209.32±80.49) pg/ml vs. (316.78±75.63) pg/ml vs. (457.78±83.21) pg/ml, t=2.016～3.167,P<0.05 all] in SAP group, UAP group and AMI group, and those of UAP group and AMI group were significantly higher than that of SAP group, t=2.173, 2.596, P<0.05; there were significant increases in IL-10 levels [(48.46±18.27) pg/ml vs. (116.45±42.76) pg/ml vs. (85.64±27.33) pg/ml vs. (70.26±18.55) pg/ml, t=2.997～2.018, P<0.05 all] in SAP group, UAP group and AMI group, and those of AMI group and UAP group were significantly lower than that of SAP group (t=2.034, 2.291, P<0.05 both). Pearson linear regression analysis indicated that serum testosterone level was negatively correlated with levels of IL-10 (r=-0.678, P<0.01) and IL-18 (r=-0.579, P<0.01) in CHD group. Conclusion: There are significant changes in serum testosterone level and plasma IL-18, IL-10 levels, and testosterone level is significantly negatively related with IL-18, IL-10 levels, and they can be regard as new indexes assessing coronary atherosclerotic lesion.