ABSTRACT
Objective:To investigate the clinical manifestations of Epstein-Barr virus infection in children and the efficacy of interferon combined with ganciclovir.Methods:A total of 252 children with Epstein-Barr virus infection who received treatment in Liaocheng Maternal and Child Health Hospital from June 2018 to February 2020 were included in this study. They were randomly assigned to undergo treatment either with ganciclovir alone (control group, n = 126) or interferon combined with ganciclovir (experimental group, n = 126). General condition, clinical manifestation, clinical outcomes, and clinical efficacy were compared between the two groups. Results:The 252 children with Epstein-Barr virus infection were divided into four groups according to different age brackets: infancy (3.97%), early childhood (53.57%), preschool (28.97%), school age (13.49%). Children at the early childhood and preschool ages accounted for high proportions. Their clinical manifestations included fever, pharyngeal congestion, cervical lymph node swelling, and pharyngeal pain. Children with hepatosplenomegaly accounted for the highest proportion (44.12%) among those at the school age, and children with binocular edema accounted for the highest proportion (10.37%) among those at the early childhood age. The time to defervesce, eyelid edema, and lymph node regression in the experimental group were (3.55 ± 1.58) hours, (3.82 ± 1.17) hours, and (9.55 ± 1.60) hours respectively, which were significantly shorter than those in the control group [(4.40 ± 1.80) hours, (5.33 ± 1.58) hours, (10.44 ± 1.66) hours, t = 3.64, 2.47, 2.67, P < 0.001, P = 0.024, 0.009]. The total response rate was significantly higher in the experimental group than in the control group [96.03% (107/126) vs. 84.92% (121/126), χ2 = 9.03, P = 0.003]. Conclusion:Epstein-Barr virus infection has different clinical manifestations in children at different ages. Interferon combined with ganciclovir is more effective on Epstein-Barr virus infection than ganciclovir alone.
ABSTRACT
To enhance speech recognition in noise, as well as tone recognition, we presented a new kind of speech coding strategy, called one-octave wavelet transform zero-crossing stimulation (WTZS), for cochlear implants based on amplitude and frequency modulation. We selected 15 volunteers with normal hearing ability to carry out hearing simulation experiments by picking up the amplitude (amplitude modulation, AM), zero-crossings (frequency modulation, FM) and gradient parameters from processed speech signal in the domain of one-octave wavelet transform to synthesize the stimulating pulstile series. The experimental results demonstrated that the phonetic recognition in quiet surroundings with amplitude modulation only strategy (CIS) is similar to that of amplitude and frequency modulations strategies (FAME and WTZS), while the tone perception of CIS is inferior to that of FAME and WTZS strategies. However, in noisy environment, the phonetic recognition, tone perception, as well as sentence recognition of WTZS strategy are better than those of CIS and FAME strategies. WTZS strategy, utilizing amplitude (AM), zero-crossings (FM) and gradient parameters to synthesize stimulus, can enhance the phonetic and tonal language recognition in noise environment effectively, and could be used in cochlear implant system for speech processor design after arithmetic optimization.
Subject(s)
Humans , Cochlear Implants , Language , Prosthesis Design , Signal Processing, Computer-Assisted , Sound Spectrography , Methods , Speech Acoustics , Speech Perception , PhysiologyABSTRACT
Objective To research and develop a novel-style wound dressing.Methods 80 patients treated with the new wound dressing of sustained-release alginate fiber were clinically observed.Result Among 90 wounds in 80 patients treated with the dressing,68 wounds healed in grade A,16 in grade B and 6 in grade C.Mean heal-time was 10.6 days.Conclusion The wound dressing of sustained-release alginate fiber is of sound biocompatibility and has many functions in speeding wound healing.