ABSTRACT
Every year approximately 450 children in the united kingdom suffer rum chronic renal failure, in Egypt we are far from this number we have more than thousands, of these about 10% under 15 years of age develop endstage renal failure. Increase survival rates occurred due to successful dialysis, technology and transplantation but secondary effects occur on enamel and delayed eruption of teeth occurred, in this study we compared 105 children with CRF with another 100 healthy control group regarding the enamel opacities using the DDE index also the severity and pattern of the defects were noticed. we concluded that the children with CRF have significantly more enamel defects and opacities than normal control group as 30% only in the control group has enamel opacities while all children in patients group suffer from some degree of enamel opacities, also the enamel defects tends to be generalized in permanent teeth while it tends to be localized in primary teeth, micro- abrasion and esthetic treatment has been done to those patents especially in the adolescent age. There is a potential for enamel opacities with CRF and modification to dental treatment is needed or the timing as well as the most appropriate antibiotics and the interception for esthetic correction of enamel defects in this young people, also this study high light for further study in the relation to other drugs lead to enamel opacities