ABSTRACT
A total of 23 samples of 21 patients designated Langerhan's cell histiocytosis [LCH] or eosinophilic granuloma was collected for this study. Light microscopy showed that the picture of LCHs was a mixture of Langerhan's [LCs] and eosinophils in varying proportions along with the occasional giant cells of foreign body and Langerhan's giant cells, lymphocytes and neutrophils. The immunohistochemical study showed mostly negative staining for alpha-1-antitrypsin. Out of the 23 specimens, 19 were positive for S100. CD Ia was performed on all cases with 100% positivity. The macrophages were negative for CD Ia and S100, but were positive for alpha-1-antitrypsin. The staining for NSE was positive for 19 specimens, but it was nonspecific as the histiocytes showed also a positive staining. All the 21 cases studied by electron microscopy had the characteristic features of Langerhans' cell histiocytosis in the form of Birbeck granules along with the deeply cleaved or pseudo-multisegmented nuclei with finely dispersed, thinly marginated chromatin and inconspicuous nucleoli
Subject(s)
Humans , Male , Female , Immunohistochemistry , Microscopy, Electron , Langerhans Cells , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Histiocytosis, Langerhans-Cell/pathologyABSTRACT
Fourteen patients with persistent oro-antral fistula following dental extraction were managed by a combined endonasal, sublabial and per-oral approach, under cover of antibiotic and metronidazole therapy. Endoscopic endonasal ethmoidectomy with middle meatal antrostomy, modified Caldwel-Luc approach and per-oral closure of the fistula mouth by a posteriorly based palatal flap was our surgical technique. Results were very satisfactory without any major complications
Subject(s)
Humans , Male , Female , Tooth Extraction/complications , Endoscopy , Surgical Flaps , Treatment Outcome , Metronidazole , Metronidazole/drug effectsABSTRACT
Nineteen patients of frontal osteoma were diagnosed in the period between May 1995 and November 1998. Five cases were asymptomatic and follow up was our policy in those cases. Four cases presented with chronic/recurrent frontal headache. Ten patients were complicated. Six showed secondary mucoceles, which extended to the orbit and/or the intracranial cavity in 5 cases. Other complications included recurrent acute sinusitis, orbital extension of the tumor, gross involvement of the anterior table of the frontal bone and osteomyelitis with fistulation. Frontal osteoplastic flap was our procedure to resect these tumors