ABSTRACT
BACKGROUND@#The hypocaloric diets improve glycemic status in obese individuals, but the response to hypocaloric diets in fat mass and obesity-associated gene (FTO)-rs9939609 gene variant is unknown. This systematic review and meta-analysis aimed to assess the gene-diet interaction of FTO-rs9939609 gene variant and hypocaloric diets on glycemic control in overweight and obese adults.@*METHODS@#Cochrane Central Register of Controlled Trials, PubMed, ISI Web of Science, Embase, Scopus, and Google scholar were searched up to December 2018, for relevant clinical trials. Mean changes in fasting blood sugar (FBS), serum insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) were extracted.@*RESULTS@#The pooled analysis of nine studies showed that there was no significant difference between AA/AT and TT genotypes in FBS (weighted mean difference [WMD] = 0.01, 95% confidence interval [CI]: -1.08, 1.10, P = 0.984) and serum insulin (WMD = 0.20, 95% CI: -0.85, 1.26; P = 0.707) after intervention hypocaloric diets. The overweight/obese participants in AA/AT group showed the greatest reduction in HOMA-IR compared with TT genotype following intervention, and this difference was not statistically significant (WMD = -0.38, 95% CI: -0.94, 0.16, P = 0.167).@*CONCLUSION@#This meta-analysis suggests that there was no significant difference between AA/AT and TT genotypes of FTO-rs9939609 on FBS, serum insulin level, and insulin resistance in response to hypocaloric diets.
ABSTRACT
Background: Despite many effort to identify and control the factors involved in polycystic ovary syndrome [PCOS], there are no available reports indicating the association of healthy eating index [HEI] and PCOS
Objective: The present study has been conducted to examine the relationship between HEI and PCOS
Materials and Methods: In this case-control study, the study population comprised 297 women aged 20-40 yr referred to Baqiyatallah Hospital Clinics, Tehran, Iran in two groups: case group [n=99] and control group [n=198]. The usual dietary data were collected using a validated 168-item semi-quantitative food frequency questionnaire. Standard anthropometric measurements [height, weight, and waist circumference] were also taken. Unconditional logistic regression was used to analyze the relationship between the PCOS and the HEI
Results: The mean age and body mass index of case and control groups were 29 +/- 5.5 vs. 29.5 +/- 6 yr and 26.6 +/- 4.8 vs. 26 +/- 4.2 kg/m[2], respectively [p=0.752, p=0.822]. Mean HEI scores for the case and control groups were found to be 61 and 65, respectively. In final model and after adjustment for confounders, the prevalence of PCOS in subjects in the highest tertile HEI score was significantly [50%] less than those in the lowest tertile HEI score [OR=0.50; 95% CI: 0.25-0.74, p=0.001]
Conclusion: Our results suggest that HEI score is inversely associated with the risk of PCOS in adult women