Protective effects of curcumin for oxidative stress and histological alterations induced by pyrethroid insecticide in Albino rats

Esfenvalerate[esfen] is a type II of synthetic pyrethroid that has replaced other groups of insecticides due to its improved insecticidal potency. The objective of this study was to investigate the toxicity of pyrethroid insecticides on liver tissues of rats and the possible role of antioxidant plant [curcumin] as a protective agent against oxidative stress and histological alterations. Forty male albino rats were divided into 8 groups of 5 rats /each: G1: served as control and G2: served as positive control received [100mg/kg curcumin], G3,G4 and G5 had oral administration [1/20 LD50, 1/40 LD50 and 1/60 LD50 of esfenvelerate] respectively and the last three groups[G6,G7and G8] were received the same doses of pesticide plus 100mg /kg curcumin for 28 days daily. Exposure of rats to [esfen] induced significant increase in the levels of MDA and significant decrease in total protein, GSH ,SOD and catalase whilst the insecticides doses plus curcumin showed decrease in MDA for high and medium dose and ameliorated the reduction of total protein concentration in low dose. We showed that curcumin acts as an effective antioxidant for esfen pesticide toxicity by reducing oxidative stress burden and histological damage

Toxicological effects of fenitrothion and vitamin E as antioxidant agent on the biochemical, cytogenetic and histopathological parameters of white rats

The use of pesticides has been increased considerably nowadays compared to the past. The hazards of using such chemical compounds have been accentuated by the sharp rise of their use in agriculture, industry, by householders and governments. Exposure to organophosphorus insecticides [OPI] in agriculture is one of the occupational hazards. Fenitrothion is one of the most important OPI. The major object of the present study was to evaluated the toxicological [biochemical, mutagenic and histopathological] effects of tested insecticide [fenitrothion] alone or combined to vitamin E as an antioxidant agent to decrease their toxic effect. male albino rats were tested orally for 30 days, three doses of fenitrothion were used in absence and presence of vitamin E [1/20, 1/40 and 1/80 LD50]. the obtained data showed marked changes in biochemical parameter, highly inhibition of AchE activity; highly significant increase in the frequency of micronucleus [PCEM] in rat bone marrow cells at all doses of fenitrothion alone or combined to vitamin compared to control group. Also, the histopathological examination of liver and kidney tissues revealed high alternation in these tissues corresponding to biochemical changes. From these results we concluded that fenitrothion exert biochemical, mutagenic and histopathological effects in white rats. In addition, vitamin E has mild role in alleviating these toxicological effects