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1.
Medical Journal of Mashad University of Medical Sciences. 2012; 55 (2): 69-75
in Persian | IMEMR | ID: emr-131405

ABSTRACT

Thalassemia major is a hereditary anemia that becomes blood transfusion dependent. Iron overload consequence leads to multiple organ dysfunction and endocrinopathy. So deferoxamine [desferal] is used for chelation therapy. The aim of this study was to evaluate the growth rate of these patients and its correlation with endocrine complications and determine the role of secondary iron overload in these situations. This cross-sectional study was performed for a year [2010] on 280 patients [aged 3.5- 56 years] who received blood transfusion and chelation therapy at Amirkola Thalassemia Center. After basic evaluations, determination of height standard deviation, they were divided by serum ferritin level into two groups [good and poorly controlled]. They were evaluated for hypothyroidism, diabetes mellitus, hypoparathyroidism and hypogonadism. Next, data were analyzed. A p <0.05 was considered significant. From 280 patients with mean age of 19.6 +/- 8.5 years, 161 [57.5%] cases were female, short stature [<-2 SDS] was present in 90 cases [32.1%]. Their mean height was 151.4 +/- 17.3 cm. 162 cases [57.9%] had endocrinopathy. There was a relationship between short stature and hypoparathyroidism [p= 0.009] and hypogonadism [p= 0.005] and also diabetes mellitus [p= 0.003]; but no relationship was found between short stature and hypothyroidism [p=1.000] and serum ferritin level [p=0.091]. According to higher prevalence of hypoparathyroidism, hypogonadism and diabetes mellitus in short statured thalassemic patients, screening should be done for such disorders with more sensitivity in these patients


Subject(s)
Humans , Male , Female , beta-Thalassemia , Dwarfism , Deferoxamine , Chelation Therapy , Cross-Sectional Studies , Body Height , Ferritins , Hypoparathyroidism , Hypogonadism , Diabetes Mellitus , Carpal Tunnel Syndrome
2.
Journal of Sabzevar School of Medical Sciences. 2007; 14 (3): 185-191
in Persian | IMEMR | ID: emr-83575

ABSTRACT

Dysmenorrhea is one of the common problems of women at the childbearing age and has social, psychological, physical and economic consequences. As emotional factors influence physical conditions and the perception of pain, this study was conducted at the University of Mashad, Iran to compare the personality features of medical students with and without early dysmenorrheal. This is a descriptive analytical and cross-sectional study and the study population was the female medical students at Mashad University of Medical Sciences in 2004. 200 students were proportionately sampled using a subject selection form. They also filled out the interview checklist, the lifestyle questionnaire and the Cassidy Social Support Form. On specific days, the menses pain intensity form, history of menses form and Eysenk Personality Questionnaire were completed. The obtained data were analyzed in SPSS using Chi square, Fischer's Exact Test, t-test, Mann Whitney and Regression model. Significant differences were found between the two groups as for the frequency of introversion: in the group with dysmenorrhea 67% and the other group only 12% were introverts. In addition, the frequency of neurosis was statistically different across the two groups [52% in the group with dysmenorrhea and 10% in the other group]. Also the two groups were statistically different in the prevalence of psychosis [72% versus 32% for the group with and without dysmenorrheal respectively]. Introversion, psychosis and neurosis were more prevalent in women with dysmenorrhea than in women without dysmenorrhea


Subject(s)
Humans , Female , Students, Medical , Cross-Sectional Studies , Dysmenorrhea
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