ABSTRACT
Vanadium compounds have antidiabetic, but there is no study about the antidiabetic effects f ammonium monovanadate nono-particles. In this study, antidiabetic effect of ammonium monovanadate was compared with its nonoparticles. In this experimental and animal modeling study, 42 male Sprague Dawley rats were divided in 6 groups [each group 7 rats]. Diabetes was induced by IP injection of 60 mg/kg streptozicin to five groups. One normal group and one diabetic group were kept without treatment as control groups. Other diabetic rats were treated with nonovanadate 25 mg/kg [NV25], ordinary vanadate 25 mg/kg [V25], nonovanadate 15 mg/kg [NV15] and water ordinary vanadate 25 mg/kg [WV25] groups for 10 days by gavage. Heparinized blood was collected at days 11 and 21 and centrifuged to separate plasma. Glycosylated hemoglobin, insulin, triglyceride [TG], total cholesterol [TC], HDL-c and LDL-c were measured at both time and compared between groups. All treatment except in V25 decreased glycemia, but insulin increased only in NV25 group [p<0.05]. All treatment decreased TG, TC and LDL-c significantly [p<0.001]. Ammonium mono vanadate nonoparticle has better effects than ordinary ammonium mono vanadate on some biochemical factors in experimental diabetes
ABSTRACT
Hyperactivity of testosterone is one cause of infertility and its incorrect use can produces reproductive disorders. Nettle [Urtica dioica] has antiandrogenic effect and may antagonized effect of testosterone. In present study structure of testes of golden hamster was evaluated after testosterone and extract. In this experimental and animal modeling study, twenty male mature hamsters were divided to 4 groups, group 1 was control, group 2 received testosterone at dose 3 mg/kg subcutaneously, group 3 received nettle extract dose 30 mg/kg orally and group 4 received testosterone and nettle for 30 days daily. The hamsters were euthanized and testes were removed and detected macroscopic parameters [weight, height, wide and volume] and fixed with formalin. The samples were sectioned and colored with H and E. The volume, weight, length and wide of testes was at least in testosterone group and statistically was lesser than control and testosterone -nettle group [p<0.05], but did not the height epithelium of seminifer tubules, compact of spermatogenic cells and number of serotolli cells in testosterone group was lesser than control group significantly [p<0.05]. The nettle extract decreased histological changes of testes by testosterone and improved its structure