ABSTRACT
Background: Upper gastrointestinal bleeding [UGIB] is an important complication of low-dose aspirin. There are few and conflicting results about the etiology of UGIB in relation to low-dose aspirin. The aim of the present study was to evaluate the upper gastrointestinal endoscopy of patients taking low-dose aspirin who developed UGIB.
Materials and methods: The medical records of patients with UGIB who referred to Fatemieh Hospital, Semnan, Iran during 2001-2011 were studied and eligible patients were enrolled to the study. The endoscopic data were extracted and compared between the patients taking low-dose aspirin and who were not taking aspirin [control].
Results: 419 cases were studied. 58 [13.8 Percent] patients consumed low-dose aspirin and 204 [48.7 Percent] patients did not consume aspirin. The average age of the patients who received low-dose aspirin and those in the control groups were 65.9 +/- 5.9 and 50.4 +/- 22.3 years, respectively [p = 0.000]. 46.6 Percent and 32.4 Percent of the patients in low-dose aspirin and control groups were women, respectively, and the remaining patients were men [p > 0.05]. The main endoscopic findings in low-dose aspirin and control groups were erosions of the stomach, duodenum, and esophagus [55.9 Percent and 51.7 Percent] and peptic ulcer [50 Percent and 43.6 Percent], respectively. The other findings such as neoplasia, Mallory Weiss, and hiatal hernia were uncommon [1.7 Percent and 5.9 Percent]. The prevalence of endoscopic findings was not statistically significant between the two groups [p > 0.05].
Conclusion: In this small study, although patients with UGIB and low-dose aspirin consumption had more peptic ulcers and erosions in comparison with the control group, the difference was not significant
ABSTRACT
Background: Reflux disease is a common gastrointestinal problem. The association between reflux disease and gastritis pattern is controversial
Aim: To determine the association between reflux disease and gastritis pattern in patients with Helicobacter pylori [H. pylori] infection
Methods: 470 patients with dyspepsia and reflux disease were enrolled in this study. The inclusion criteria were willing to participate in the study, age over 40 years, and having the criteria of ROME III for at least 3 months. Patients with history of H. pylori eradication therapy during the 3 months before the study, a history of gastric surgery, and gastric cancer were excluded. All of the participants underwent upper endoscopy and two biopsy samples were taken from antrum, body, and fundal areas
Results: H. pylori infection rate was 367 [78.1%] with mean age of 59.8 +/- 11.4 years. Of them 131 patients [35.7%] were male. Reflux disease was detected in 273 [74.4%] patients. 216 [58.9%] and 102 [27.8%] patients had non-erosive reflux disease [NERD] and gastroesophageal reflux disease [GERD], respectively. Corpus predominant and antral predominant gastritis were seen in 72 [19.6%] and 129 [35.2%] patients, respectively. Antral gastritis was significantly associated with GERD [p<0.01]. In regression analysis, antral predominant gastritis had a significant association with GERD [OR=1.92; 95%CI: 1.22-3.12]. The same result was observed in mild to moderate antral and greater curvature gastritis [OR= 1.26; 95%CI: 0.25-6.40 and OR= 3.0; 95%CI: 0.63-14.17, respectively]
Conclusion: According to these finding, we could suggest that the pattern of gastritis could be associated with reflux disease and GERD
ABSTRACT
Juvenile hemochromatosis is a rare autosomal recessive disorder that typically occurs in the first to third decades of life. Its symptoms are more acute and severe than classic hemochromatosis. We describe a 27-year-old man who was referred to the gastrointestinal clinic with a probable diagnosis of fatty liver and was finally diagnosed as having juvenile hemochromatosis. A review of the scientific literature reveals that recently only three siblings suffering from the disease have been reported in Iran
ABSTRACT
Background: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome [PCOS], and therefore vitamin D receptor [VDR], parathyroid hormone [PTH], and insulin receptor [INSR] gene variants might be involved in the pathogenesis of PCOS
Objective: The present study was designed to investigate the possible associations between polymorphisms in VDR, PTH, and INSR genes and the risk of PCOS
Materials and Methods: VDR, PTH, and INSR gene variants were genotyped in 35 women with PCOS and 35 controls using Polymerase chain reaction - Restriction fragment length polymorphism method. Furthermore, serum levels of glucose and insulin were measured in all participants
Results: No significant differences were observed for the VDR Fokl, VDR Tru9l, VDR TaqI, PTH Drall, INSR Nsil, and INSR Pmll gene polymorphisms between the women with PCOS and controls. However, after adjustment for confounding factors, the VDR BsmI "Bb" genotype and the VDR Apal "Aa" genotype were significantly under transmitted to the patients [p= 0.016; OR= 0.250; 95% CI= 0.081-0.769, and p= 0.017; OR= 0.260; 95% CI= 0.086-0.788, respectively]. Furthermore, in the women with PCOS, insulin levels were lower in the participants with the INSR Nsil "NN" genotype compared with those with the "Nn + nn" genotypes [P= 0.045]
Conclusion: The results showed an association between the VDR gene Bsml and Apal polymorphisms and PCOS risk. These data also indicated that the INSR "NN" genotype was a marker of decreased insulin in women with PCOS. Our findings, however, do not lend support to the hypothesis that PTH gene Drall variant plays a role in susceptibility to PCOS
ABSTRACT
Hereditary hemochromatosis is a common cause of chronic liver disease in western countries. No report of this disease has appeared from Iran and the few studies which have focused on chronic liver disease have failed to identify a single case of hemochromatosis. In this report, we present the first case of hereditary hemochromatosis during our 25 years of gastroenterology practice in Iran