ABSTRACT
Transurethral resection of prostate [TURP] is the most common urological operation performed. Regarding the complications of this surgery, studies are looking for alternative endoscopic techniques in order to reduce risk of complications. Use of high energy lasers is the most promising method for managing patients with benign prostate hyperplasia [BPH]. In this study, we evaluated the effect of homemade KTP laser on resected prostate adenoma after open prostatectomy. A total of forty resected prostate adenoma by open prostatectomy, assigned in to the study groups. One part of specimens without any intervention was sent to the pathology department and the rests divided to four KTP dose response groups [10 patients in each group]. The prostate specimens were ablated by KTP laser in one, two, three, and four sessions according to their number of subgroups. Prostate tissue was irradiated by 5-watt KTP laser for 15 seconds in each stage. All prostate specimens ablated with laser were sent to pathology for evaluation of tissue ablation capacity and tissue penetration depth. Mean age of the participants was 73.25 +/- 6.8 years with mean serum level PSA of 3.65 +/- 2.1 ng/dl. 1 to 2 mm of the tissue was ablated at each session of laser administration. In pathologic examination, 0 to 2 mm of tissue destruction with disappearance of nuclei of the cells, basophilia of the stroma, and damaged tissue [cutter like effect] were witnessed. Findings were compatible with burn effect. KTP laser prostatectomy is a safe and effective procedure with low risk of complications in which bladder outlet obstruction symptoms will relieve. According to our study, extra penetration of prostate tissue during laser irradiation is rare. This finding could be suggestive this theory that KTP laser has little risk of capsule perforation