Bendamustine-induced immune hemolytic anemia in a chronic lymphocytic leukemia patient: a case report and review of the literature

Bendamustine is an alkylating agent approved for the treatment of chronic lymphocytic leukemia [CLL] and B-cell non-Hodgkin lymphoma. There are scant reports on bendamustine-induced immune hemolytic anemia occurring mainly in CLL patients. We report a case of immune hemolytic anemia that developed after exposure to bendamustine in a 70-year-old female with CLL who was previously exposed to fludarabine. Previous exposure to fludarabine is a common finding in the majority of reported cases of bendamustine drug-induced immune hemolytic anemia [DIIHA], including our case. Bendamustine should be suspected as the cause of any hemolytic anemia that develops while on this drug, especially in CLL patients treated previously with fludarabine

Eosinophilic fasciitis as a paraneoplastic syndrome, a case report and review of the literature

Eosinophilic fasciitis [EF] is a rare disease with characteristic clinical and histological features, previously reported to be associated with various hematological and solid malignancies. We report a typical case of eosinophilic fasciitis in a 67-year-old man in association with myelodysplastic syndromes [MDS]/acute myeloid leukemia [AML] and subsequently bladder cancer. On the two occasions, the eosinophilic fasciitis completely resolved upon successful treatment of the concomitant malignancy. The diagnosis of EF should trigger further evaluation for any associated hematological disorder, which, if adequately treated, can result in the resolution of EF