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OBJECTIVE: To investigate the effect of the power-frequency electromagnetic field on antioxidant indexes in operation personnel. METHODS: By random sampling method,a total of 58 workers who work in 500 kV transformer substations for at least 5. 0 years were selected as the exposure group,and 60 administrative staffs in the same enterprise were included as the control group. The power frequency electromagnetic fields in the 2 groups were measured. The cumulative exposure dose of individual magnetic field was calculated. Peripheral venous blood was collected in these 2groups and was examined with the superoxide dismutase( SOD) activity,malondialdehyde( MDA) level and the relative gene expression level of manganese superoxide dismutase( MnSOD). RESULTS: There was no statistical significance in the SOD activity,MDA level and the relative gene expression level of MnSOD between the exposure group and the control group( P > 0. 05). The logistic regression analysis results indicated that cumulative exposure dose was not correlated with the SOD activity,MDA level and the relative gene expression level of MnSOD after adjusting confounding factors such as age,smoking,alcohol and tea drinking( P > 0. 05). CONCLUSION: Power-frequency electromagnetic field exposure has no significant effects on the SOD activity,MDA level and the relative gene expression level of MnSOD of operation workers.
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OBJECTIVE: To examine the effects of long-term exposure to power frequency electromagnetic fields on the occurrence of micronucleus in peripheral blood lymphocytes and the lymphocyte transformation in transformer substation workers. METHODS: By simple random sampling method,54 workers exposed to power frequency electromagnetic fields for more than 1. 0 year and other 54 non-exposure workers in 500 kV transformer substations were chosen as the exposure group and control group,respectively. The peripheral venous blood of subjects in these two groups was collected,and then the lymphocytes were separated. The micronucleus cell rate,the micronucleus rate and the lymphocyte transformation rate were detected and analyzed. RESULTS: Compared with the control group,the micronucleated cell rate,the micronucleus rate,and the lymphocyte transformation rate of the exposure group and its different length of service subgroups( ≤ 10. 0and > 10. 0 years) showed no statistical significance respectively( P > 0. 05). CONCLUSION: The long-term exposure to power frequency electromagnetic fields has no obvious effects on the micronucleus and lymphocyte transformation in the peripheral blood lymphocytes of exposed workers.
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OBJECTIVE: To explore the effects of long-term exposure to power frequency electromagnetic fields on the humoral immune function in transformer substation workers. METHODS: By simple random sampling method,64 workers with length of service longer than 5. 0 years in 500 k V transformer substation were chosen as exposure group and 57 general administrative staffs without exposure to power frequency electromagnetic field were chosen as control group. Venous blood was collected from subjects of these two groups and the levels of immunoglobulin( Ig) A,Ig G,Ig M,complement( C) 3and C4 in plasma were examined by immunoturbidimetry. RESULTS: Compared with the control group,the levels of both Ig A and Ig G increased( P < 0. 05),while both levels of C3 and C4 decreased( P < 0. 05) in exposure group. Compared with the control,the level of Ig G increased( P < 0. 05),while the levels of both C3 and C4 decreased( P < 0. 05) in exposure subgroup with length of service ≤10. 0 years. The level of C4 decreased( P < 0. 05) in exposure subgroup with length of service > 10. 0 years. CONCLUSION: Long-term exposure to power frequency electromagnetic fields may activate the humoral immune function in transformer substation workers.
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Objective To explore the relationship among high homocysteine hypertension(H-type hypertension), early enlargement of hypertensive intracerebral hematoma and its clinical outcome and death within 3 months. Methods A total of 298 cases with primary cerebral hemorrhage were selected in this study. The data including general information,brain CT scan results within 6 and 24 h, the values of homocysteine(Hcy), blood glucose,cholesterol and fibrinogen, and the scores of National Institute of Health Stroke Scale(NIHSS)were collected. After 3 months follow-up, modified Bathel(MBI)scores and the death tolls were collected as well. Results The increase of plasma Hcy level(odds ratio[OR]=0.356, 95% confidence interval [CI]: 0.131-0.826;P＝0.021)and the elevation of systolic pressure(OR=1.021,95% CI: 1.002-1.028;P＝0.045)were independent risk factors of enlargement hematoma of primary cerebral hemorrhage. The increase of plasma Hcy level(OR=1.031, 95% CI: 1.021-1.278;P＝0.035)and the elevation of systolic pressure(OR=1.141, 95% CI: 1.011-1.072;P＝0.034)were the independent risk factors of clinical poor outcome. Besides,the elevation of systolic pressure(OR=1.023,95% CI: 1.007-1.051;P＝0.021), higher blood glucose(OR=1.382,95% CI: 1.221-1.673;P＝0.004), and the increase of Hcy level(OR=1.521, 95% CI: 1.025-8.096;P＝0.023) were the independent risk factors of death within 3 months. Conclusion H-type hypertension is the independent predictor of early enlargement of hematoma and clinical outcome and death of primary cerebral hemorrhage.