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Chinese Journal of Hepatology ; (12): 754-758, 2009.
Article in Chinese | WPRIM | ID: wpr-306679

ABSTRACT

<p><b>OBJECTIVE</b>To study the change of intestinal mucosa barrier in chronic severe hepatitis B patients and clinical intervention.</p><p><b>METHOD</b>(1) 30 normal healthy controls and 60 chronic severe hepatitis B patients were enrolled in this study. The change of intestinal permeability was determined by urine lactulose/ mannitol ratio (L/M), and the serum diamine oxidase (DAO) was measured. (2) 60 chronic severe hepatitis B patients were randomly divided into two groups: the control group and the treated group, each group has 30 cases. Patients in the control group received standard treatment for 2 weeks, however, in addition to standard treatment, patients in the treated group also received glutamine 10g tid. Endotoxin (ET), DAO and L/M were compared between the two group.</p><p><b>RESULTS</b>(1) Compared to healthy controls, the level of L/M and DAO was significantly increased in chronic severe hepatitis B patients (t = 2.762, P less than 0.01 or t = 6.326, P less than 0.01). (2) Compared to the control group, ET, DAO and L/M were significantly lower 2 weeks after treatment (F = 11.662, P less than 0.01; F = 12.699, P less than 0.01; F = 19.981, P less than 0.01).</p><p><b>CONCLUSION</b>(1) There is an early intestinal mucosa barrier damage in chronic severe hepatitis B patients. (2) Compared to standard treatment, adding glutamine can reverse intestinal mucosa barrier damage.</p>


Subject(s)
Adolescent , Adult , Child , Female , Humans , Male , Middle Aged , Young Adult , Administration, Oral , Amine Oxidase (Copper-Containing) , Blood , Antiviral Agents , Pharmacology , Therapeutic Uses , Endotoxins , Blood , Glutamine , Pharmacology , Therapeutic Uses , Hepatitis B, Chronic , Drug Therapy , Metabolism , Intestinal Mucosa , Metabolism , Intestine, Small , Lactulose , Urine , Mannitol , Urine , Permeability , Treatment Outcome
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