ABSTRACT
OBJECTIVE To understand pathogen distribution and drug resistance of urinary system infection in Langfang,then help the clinic to use drug rationally.METHODS Totally 846 bacteria were isolated from the urine and given in vitro drug sensiticity test with Kirby-Bauer method to detect special resistant strains such as MRS,VRE,HLAR and the ESBLs-producing bacteria.RESULTS The first 5 were Escherichia coli(60.2%),cogulase negative Staphylococcus (CNS,16.7%),Klebsiella pneumoniae(3.2%),Enterococcus(2.6%),and Proteus(2.1%).ESBLs-producing bacteria were 23.5%,MRS were 83.7%,HLAR were 59.1%,VRE were not detected.E.coli was sensitive to cefepime,piperacillin/tazobactam,ceftazidime,amikacin(71.0-99.0%).CNS was sensitive to vancomycin,piperacillin/tazobactam,nitrofurantoin,and ofloxacin(70.0-100.0%).Vancomycin-resistant CNS was not detected.CONCLUSIONS E.coli is the most encountered pathogen causing urinary system infection in Langfang,Then are CNS.Antibiotics we were used such as gentamicin,ciprofloxacin,et,al already produced higher resistance,so clinic should consider the drug sensitivity agent and special resistant strain and choice antibiotics rationally,to make the resistant streains decreasing in number.