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Oridonin is one of the main anti-tumor active ingredients of Rabdosiae Rubescentis Herba. In the development process of a variety of malignant tumors, such as liver cancer, breast cancer, cervical cancer, pancreatic cancer, lung cancer, gastric cancer, esophageal cancer, colon cancer, etc, it has a significant inhibitory effect. Oridonin plays the rold of anti-tumor effect mainly by inhibiting tumor cell proliferation, inducing tumor cell apoptosis, inhibiting tumor cell invasion and migration, inducing tumor cell autophagy, reducing telomerase activity and reversing the drug resistance of the tumor cell.
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Objective To investigate the clinical effectiveness and safety of acupuncture at Zusanli (ST36),Taichong(LR3) and Hegu(LI4) points combined with three-step analgesic ladder for the treatment of gastric cancer pain.Methods Sixty patients with moderate and severe pain induced by gastric cancer were randomly divided into study group and control group,30 cases in each group.The study group was treated with acupuncture at Zusanli,Taichong and Hegu points combined with three-step analgesic ladder for gastric cancer pain management,and the control group was treated with three-step analgesic ladder only.After treatment for 7 days,the clinical effectiveness was evaluated with the average pain scores of Numerical Rating Scale(NRS),Quality of Life Scale(QOL-BREF by WHO),Self-rating Depression Scale(SDS).And the incidence of adverse reaction was also observed.Results (1) After treatment,the markedly-effective analgesic rate of the study group was higher than that of the control group (P ＜ 0.05).(2) After treatment,QOL scores of both groups were much improved as compared with those before treatment(P ＜ 0.05),and the improvement of the study group was superior to that of the control group(P ＜0.05).(3) The depression scores of both groups were much improved after treatment (P ＜ 0.05 compared with those before treatment),but the difference between the two groups was insignificant(P ＞ 0.05).(4) The incidence of adverse reaction of the study group was lower than that of the control group(P ＜ 0.05).Conclusion The effect of acupuncture at Zusanli,Taichong and Hegu points combined with three-step analgesic ladder is better than three step analgesic ladder alone for the treatment of gastric cancer pain.
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OBJECTIVE:To observe the therapeutic efficacy and safety of modified Liujunzi decoction in adjuvant chemotherapy for advanced non-small cell lung cancer (NSCLC).METHODS:A total of 118 patients with advanced NSCLC were randomly divided into observation group and control group,with 59 cases in each group.Both groups were given Dexamethasone acetate tablets 15 mg orally 12,6 h before chemotherapy,Diphenhydramine hydrochloride injection 20 mg intramuscularly 30 min before chemotherapy,and also given routine treatment as acid suppression,liver protection,antiemetic,hydration and dieresis.Control group was additionally given Paclitaxel injection 175 mg/m2 intravenously within 3 h,d1,and 30 min later given Cisplatin for injection 25 mg/m2 intreavenously for 2 h,d1-3.Observation group was additionally given modified Liujunzi decoction,decocted to 200 mL,one dose a day,morning and night,on the basis of control group.A treatment course of 2 groups lasted for 21 d,and both received 4 courses.The short-term efficacies of 2 groups were observed.The levels of T lymphocyte subset and tumor marker (CEA,SCC-Ag,CYFRS21-1),the occurrence of toxic reaction were observed before and after chemotherapy.RESULTS:Total response rate of observation group (49.15％) was significantly higher than that of control group(32.20％);the incidence of thrombocytopenia,leucopenia,abnormal liver function,digestive tract reaction and peripheral nerve injury was significantly lower than control group,with statistical significance (P＜ 0.05).After treatment,CD4+ and CD4+/CD8+ of observation group were significantly higher than before chemotherapy,while CD8+ was significantly lower than before chemotherapy;CD4+ and CD4+/CD8+ of control group were significantly lower than before chemotherapy,while CD8+ was significantly higher than before chemotherapy;CD4+ and CD4+/ CD8 + of observation group were significantly higher than those control group,while CD8 + was significantly lower than control group;The levels of tumor markers in 2 groups were significantly lower than before chemotherapy,and the observation group was significantly lower than the control group,with statistical significance (P＜0.05).CONCLUSIONS:Based on routine treatment,modified Liujunzi decoction shows significant therapeutic efficacy for NSCLC,improves immune function and relieve toxic reaction.
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Biejiajian Pills was created by ZHANG Zhong-jing of Han Dynasty. Its feature was harmonizing qi-blood, appllying drugs with nature of cold and heat, and simultaneous application of purging-tonifying therapy, it was a distinguished prescription of treating malarial nodule. Today, the prescription was applied in treating liver fibrosis and had obvious effect. According to the TCM theory, Professor CHEN Zhi-qiang identified the theory of treating kidney by Biejiajian Pills on basis of analyzing the etiopathogenisis and pathogenesis of liver fibrosis and kidney fibrosis. It has made certain progress in the treatment kidney fibrosis by ancient medical prescription.
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OBJECTIVE: To study the protective efffects of Chailing Guiqi Decoction (CLGQD) combined with lumbrukinase on renal function in rats with adriamycin nephropathy. METHODS: Thirty-six SD rats were randomly divided into four groups: normal control group, untreated group, simvastatin-treated group and CLGQD -treated group. Adriamycin nephropathy was induced by intravenous injection with 5 mg/kg adriamycin. After seven-day treatment, quantitative measurement of 24-h urine protein was determined with trichloroacetic acid, and serum total protein (TP), albumin (Alb), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine (Cr) and blood urea nitrogen (BUN) were assessed using automatic biochemistry analyzer. The pathomorphological changes of renal tissues were observed with light and electron microscopes. RESULTS: In the untreated group, the 24-h urine protein excretion, serum TC, TG, LDL, Cr and BUN were significantly higher than those in the normal control group (P<0.05 or P<0.01), while the serum TP, Alb, HDL were significantly lower than those in the normal control group (P<0.01). In the CLGQD-treated group, the 24-h urine protein excretion, serum TC, TG, LDL, Cr and BUN were significantly lower as compared with those in the untreated group (P<0.05 or P<0.01), while the serum TP, Alb and HDL were significantly higher as compared with those in the untreated group (P<0.05 or P<0.01). The pathomorphological findings of the renal tissues under the light microscope in the untreated group showed focal segmental glomerulosclerosis in a few of glomerulus, degenerated and swelled proximal tubular epithelial cells, proteins in cast formation in some renal tubules and scattered fibrosis in interstitial tissues of the kidney, while the electron microscope images showed the fusion of foot processes in glomerular epithelial cells. The pathomorphological changes in the CLGQD-treated group were slighter than those in the untreated group. CONCLUSION: CLGQD combined with lumbrukinase can reduce proteinuria, regulate lipid metabolism, protect renal function, and delay progressive renal damage in rats.
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Objective To study the role of ligustrazine injection on collagen-Ⅲ(Col-Ⅲ) and laminin(LN) in pulmonary fibrosis rats induced by bleomycin A5.Methods Seventy Wistar rats were divided into 5 groups at random:normal group,model group,large-dose group,middle-dose group,little-dose group.The other groups were injected bleomycin A5 in intratrache except for normal group.From the second day,large-dose group,middle-dose group,little-dose group were given ligustrazine injection by intraperitoneal injection to 28th day,the dose was dividedly:250,150,40 mg/(kg?d).Col-Ⅲ and LN in serum were detected in 14th,28th days and the content of them in lung tissue homogenate in 28th day were also detected.HE staining was detected on lung tissue.Results The contents of Col-Ⅲ and LN of lung tissue and serum in pulmonary fibrosis rats were significantly upgraded compared with that of normal group(P