ABSTRACT
Haemocoagulase agkistrodon for injection is a kind of protein hemostatic which is purified from snake venom of Agkistrodon acutus , the hemostatic mechanism of the drug is it that the removal of fibrinogen from fibrinogen in blood can make it into monomeric fibrin after entering the body and enhance coagulation function . Preclinical results showed that the drug can significantly shortened the time of tail bleeding in mice and coagulation time of whole blood in rabbits .Clinical studies show that the medicine has a safe and effective hemostatic effect on incision in abdominal,thyroid,department of obstetrics and gynecology ,department of urology,and the hemostatic effect of thoracic incision is not obvious .In this review,the research progress on the efficacy and safety of Agkistrodon acutus thrombin in clinical hemostasis were reviewed .
ABSTRACT
Objective To evaluate the therapeutic effect of percutaneous vertebroplasty good cement dispersion within the vertebral body fracture line.Methods The clinical data of 105 osteoporotic compression fracture patients with single vertebral fractures treated by vertebroplasty were retrospectively analyzed.Including 51 males,54 females,aged 61 to 82 years,mean 75.18 years,duration of 1d to 2 months,compressed segments distributed in the T9-L3.Preoperative patients received X-ray film,routine CT scan and reconstruction and MRI examination to determine the responsibility of patients with vertebral fracture line position,intraoperative puncture position to the fracture line in the C arm guidance,and bone cement was injected,puncture used unilateral or bilateral,injection of bone cement in an amount of 3-5mL.The visual analogue pain score(VAS)was recorded before and after surgery for 48h and at the last follow-up.Results All patients were successfully completed without serious complications,intraoperative real-time C-arm fluoroscopy and postoperative review X-ray showed that bone cement in the fracture line was well dispersed.Operation time was 25-50min,average 36min.The amount of injection of bone cement within the vertebral body was 3-5mL,average 3.6mL.2 cases of bone cement leakage vertebrae forward,leakage to posterior vertebral body(vertebral canal)in 1 cases,cement leakage rate was 2.8%(3/105),no clinical symptoms.The follow-up period was 6-12 months and the mean follow-up was 7 months.The VAS score between postoperative 48 h and before operation had statistically significant difference[(2.3±0.4)points vs.(7.7±0.7)points,t=-38.72,P<0.05].The VAS score of the last follow-up was(2.2±0.5)points,which was significantly different compared with that before operation(t=-39.21,P<0.05).Conclusion PVP can effectively alleviate the pain caused by osteoporotic compression fractures and improve dysfunction,bone cement manipulation operation preferably dispersed in the fracture line can better improve efficacy.