ABSTRACT
To probe the genetic background and immunopathogenesis of dilated cardiomyopathy (DCM) 77 patients with DCM, HLA-DRB1 gene polymorphism were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique and autoantibody against myocardial mitochondria ADP/ATP carrier were examined by using the Immunoblot analysis. The frequency of HLA-DRB1*0901 allele was significantly higher in DCM patients in which autoantibody against ADP/ATP carrier of myocardial mitochondria is positive in contrast with those in which the autoantibody is negative (25.46% vs 3.45%, P < 0.05), the relative risk (RR) being 9.56. The other frequencies of HLA-DRB1 alleles have no significant difference in the antibody positive group and negative group. It is possible that a subset of DCM patients may exist in which autoimmunity is associated with genetic factors.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Autoantibodies , Allergy and Immunology , Cardiomyopathy, Dilated , Genetics , Allergy and Immunology , HLA-DR Antigens , Genetics , Allergy and Immunology , HLA-DRB1 Chains , Mitochondria, Heart , Allergy and Immunology , Mitochondrial ADP, ATP Translocases , Allergy and ImmunologyABSTRACT
AIM:To study the effects of changing right heart load on electrophysiologic parameters in anesthetized dogs. METHODS:Change of right atrial and ventricular load, right atrial and ventricular diastolic threshold (ADT, VDT), right atrial and ventricular relative refractory period (ARRP,VRRP) and right atrial and ventricular effective refractory period (AERP, VERP) were recorded. RESULTS: Increasing right heart load step by step(grade A and B) caused prolongation of ARRP, AERP, VRRP (grade B, P