ABSTRACT
@#AIM: The changes of optic disc and macular blood flow in POAG patients with different symptom types of traditional chinese medicine(TCM)were detected by OCTA, and the correlation between them and optic nerve damage was analyzed.<p>METHODS: Totally 103 eyes of 103 POAG patients were classified according to the different symptom types of TCM. The vascular density of optic disc, the vascular density of macular area, the thickness of peripapillary retinal nerve fiber layer(pRNFL), and the thickness of ganglia cell complex(GCC)were collected by OCTA, and then the differences among them were analyzed. The correlation between the blood flow parameters and visual field of mean deviation(MD)was also analyzed. <p>RESULTS: There were significant differences in best corrected visual acuity(BCVA), intraocular pressure(IOP)and course of disease among the three groups of POAG patients(<i>F</i>=29.671, 13.05, 108.60; all <i>P</i><0.01). The differences in macular GCC thickness, pRNFL thickness, optic disc vascular density and macular vascular density in different regions among the three groups were significant(<i>P</i><0.01). Linear positive correlation were found between optic disc vascular density, macular vascular density and visual field MD(<i>r</i>=0.591, 0.402, all <i>P</i><0.001).<p>CONCLUSION: OCTA can be used as an evaluation index for POAG patients with different symptom types, and it can provide a strong objective theoretical basis for the treatment of POAG.
ABSTRACT
Objective To investigate the diagnostic significance of optical coherence tomography angiography (OCTA) in the detection of primary glaucoma.Methods Totally 70 patients (116 eyes) of primary glaucoma were selected as the experimental group and 20 normal subjects (36 eyes) as the control group.The changes in macular vessel density,macular retinal ganglion cell (RGC) thickness,macular thickness,and optic disc retinal pigment epithelium (RPE) opening distance were measured by OCTA,and the correlation between the parameters and the mean deviation (MD) of visual field.Results When compared with the control group,the upper macular thickness,inferior macular thickness,macular RGC thickness and macular vessel density were reduced in the experimental group (all P ＜ 0.05).There was no significant difference in optic disc RPE opening distance between the control group and the experimental group (F =2.646,P =0.051 3).Linear positive correlations were found between macular thickness,macular RGC thickness,macular vessel density and MD (all r ＞ 0.5,P ＜0.01).The area under the curve of the diagnostic ROC curve of the macular vessel density,macular RGC thickness and mactlar thickness for glaucoma were all greater than 0.7.Conelusion There are linear positive correlations between macular thickness,macular RGC thickness,macular vessel density and MD.The parameters have a high diagnostic ability for the primary glaucoma.OCTA is a valuable technique for detecting glaucoma.
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AIM:To evaluate the morphological and functional changes of retinas induced by treatment of tunicamycin with optical coherence tomography (OCT) in rats.METHODS:Totally 60 SD rats were randomly divided into 3 groups (20 in each group), 0.5mg/kg (in low dose group), 1.5mg/kg (in high dose group) tunicamycin were injected into vitreous cavity and saline (9g/L NaCl) were injected in the same dose as a control group.Changes of retinas were observed by OCT on the 1,7 and 14d after treatment of tunicamycin.Then the rats were sacrificed, retinas were taken out and embedded by the paraffin, tissue sections and the HE staining were performed.RESULTS:OCT results suggested that tunicamycin played damage effects on retinal morphology and structure which appeared a time-and dose-dependent.Fundus photography results suggested that 2wk after tunicamycin treatments, with the gradually changing of tunicamycin concentration, peripheral retinal and macular region became pale color gradually, edema occurred in optic disk, retinal vessels appeared thinner in the high dose group, optic nerve came out atrophy.Fluorescein angiography confirmed that tunicamycin injection in vitreous cavity 2wk later, retinal vessels injury occurred, resulted in leaking of intravascular contrast agent from peripheral to the central part of the retinas.Electrophysiological data showed that retinal electrogram occurred disorder induced by tunicamycin, such as the amplitude of a wave, b wave decreased gradually, even closed to zero, which was very different from control significantly (P<0.05).HE staining of paraffin sections showed that retina injuries induced by tunicamycin were in dose-time dependent, which was consistent with the results of OCT.CONCLUSION: Clinical retinal diseases could be simulated by retinal damage animal model induced by tunicamycin treatment.OCT detection offered real-time images of the retinal cross-section, which provided a helpful non-invasive method for detecting and evaluating the retinal damages.