ABSTRACT
Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.
Subject(s)
Alkaloids , Pharmacology , Anti-Bacterial Agents , Chemistry , Pharmacology , Holarrhena , Chemistry , Methicillin-Resistant Staphylococcus aureus , Microbial Sensitivity Tests , Plant Extracts , Chemistry , Pharmacology , Staphylococcus aureusABSTRACT
Three compounds were isolated from the extract of Taxus cuspidta Sibe et Zucc with the column chromatography on silica gel and preparative HPLC methods. Their structures were identified according to the physicochemical properties and spectral analysis, and they were identified as (E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol (1), 2-deacetoxy-7beta, 9a, 10beta-trideacetyltaxinine J (2) and (3aS, 4aR, 6S, 8S, 8aS, 9R, 10R, 10aS)-benz[f]azulene-6, 8, 9, 10 (3H)-terol, 3a, 4, 4a, 5, 6, 7, 8, 8a, 9, 10-decahydro-10a-(1-hydroxyl-1-methylethyl)-1, 8a-dimethyl-5-methylene (3). Among them, compound 1 was a new compound, and compounds 2, 3 were two novel natural products.
Subject(s)
Azulenes , Chemistry , Coumarins , Chemistry , Inositol , Chemistry , Molecular Structure , Plants, Medicinal , Chemistry , Taxoids , Chemistry , Taxus , ChemistryABSTRACT
Chemical constituents of the roots and stem of Salacia hainanensis Chun et How were isolated and purified with column chromatography on silica gel, Sephadex LH-20 and preparative HPLC. Their structures were elucidated based on physicochemical and spectral spectroscopic analysis. Depending on the activities of anti-alpha-glucosidase and inhibiting AGEs (advanced glycation end products, AGEs) formation in vitro, nine compounds were identified as 26, 27-dihydroxy-7, 24-tirucalladien-3-one (1), abruslactone A (2), lupeol (3), 21alpha, 30-dihydroxy-D: A-friedooleanan-3-one (4), 15alpha-hydroxyfriedelan-3-one (5), friedelin (6), mangiferin (7), epicatechin (8) and beta-sitosterol (9), separately. Among them, compound 1 is a new compound, and compound 2 was isolated from the Salacia genus for the first time, while, compounds 3, 4, 5, 8 were obtained from this plant for the first time.
Subject(s)
Catechin , Chemistry , Molecular Structure , Pentacyclic Triterpenes , Chemistry , Plant Roots , Chemistry , Plant Stems , Chemistry , Plants, Medicinal , Chemistry , Salacia , Chemistry , Steroids , Chemistry , Triterpenes , Chemistry , Xanthones , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents of Caesalpinia minax.</p><p><b>METHOD</b>The chemical constituent was isolated by various chromatographic metheds and its structure was elucidated by the analysis of spectral data and physiochemical properties.</p><p><b>RESULT</b>One diterpenoid compound was isolated from the 95% ethanolic extract of C. minax, and identified as 12alpha -methoxyl-14beta-hydroxy-lalpha, 6alpha, 7beta-triacetoxycass-13 (15)-en-16, 12-olide.</p><p><b>CONCLUSION</b>Neocaesalpin L1 was a new compound and named as neocaesalpin L1.</p>
Subject(s)
Caesalpinia , Chemistry , Diterpenes , Chemistry , Drugs, Chinese Herbal , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents of Mentha spicata.</p><p><b>METHOD</b>The chemical constituents were isolated by silica gel column chromatography, and identified by physical and chemical characters and spectroscopic analysis.</p><p><b>RESULT</b>Compounds I - V were obtained and their structures were elucidated as protocatechuic aldehyde (I), protocatechuic acid (II), chrysoeriol (III), 5, 6-dihydroxy-7, 8, 3', 4'-tetramethoxyflavone (IV), nodifloretin (V).</p><p><b>CONCLUSION</b>Compound I and II were first isolated from the genus Mentha. Compound Ill, IV and V were isolated from M. spicata for the first time.</p>
Subject(s)
Benzaldehydes , Chemistry , Catechols , Chemistry , Drugs, Chinese Herbal , Chemistry , Flavones , Chemistry , Flavonoids , Chemistry , Hydroxybenzoates , Chemistry , Mentha spicata , Chemistry , Plants, Medicinal , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents of Fagopyrum cymosum.</p><p><b>METHOD</b>The chemical constituents were isolated by various chromatographic methods and their structures were elucidated by the analysis of spectral data and physiochemical properties.</p><p><b>RESULT</b>Four phenolic acid derivatives were isolated from F. cymosum. The chemical structures were elucidated as trans-p-hydroxy cinnamic methyl ester (I), 3, 4-dihydroxy benzamide (II), protocatechuic acid (III), protocatechuic acid methyl ester (IV).</p><p><b>CONCLUSION</b>Compounds I, II, IV were obtained from the genus Fagopyrum for the first time.</p>