1.
Chinese Journal of Anesthesiology
;
(12)1996.
Article
in Chinese
| WPRIM
| ID: wpr-521016
ABSTRACT
Objective To determine if propofol can affect uptake of dopamine ( DA) by dopamine transporter (DAT) . Methods Chinese hamster ovary (CHO) cells in which DAT was highly expressed were incubated with H-dopamine in the presence or absence of propofol. Uptake of H-DA was measured. The kinetic parameters Vmax and Km were calculated. Results Propofol significantly inhibited uptake of DA by DAT in CHO cells as compared with the control ( P