ABSTRACT
OBJECTIVE@#To investigate the effect of dexmedetomidine combined with pulmonary protective ventilation against lung injury in patients undergoing surgeries for esophageal cancer with one-lung ventilation (OLV).@*METHODS@#Forty patients with undergoing surgery for esophageal cancer with OLV were randomly divided into pulmonary protective ventilation strategy group (F group) and dexmedetomidine combined with protective ventilation strategy group (DF group; =20). In F group, lung protective ventilation strategy during anesthesia was adopte, and in DF group, the patients received intravenous infusion of dexmedetomidine hydrochloride (0.3 μg · kg ·h) during the surgery starting at 10 min before anesthesia induction in addition to protective ventilation strategy. Brachial artery blood was sampled before ventilation (T), at 30 and 90 min after the start of OLV (T and T, respectively) and at the end of the surgery (T) for analysis of superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), arterial oxygenation pressure (PaO), oxygenation index (OI) and lung compliance (CL).@*RESULTS@#At the time points of T, T and T, SOD level was significantly higher and IL-6 level was significantly lower in the DF group than in F group ( < 0.05). The patients in DF group showed significantly higher PaO, OI and CL index than those in F group at all the 3 time points.@*CONCLUSIONS@#Dexmedetomidine combined with pulmonary protective ventilation strategy can reduce perioperative lung injury in patients undergoing surgery for esophageal cancer with OLV by suppressing inflammation and oxidative stress to improve lung function and reduce adverse effects of the surgery.
Subject(s)
Humans , Dexmedetomidine , Esophageal Neoplasms , Therapeutics , Lung , Malondialdehyde , One-Lung VentilationABSTRACT
OBJECTIVE@#To investigate the effect of dexmedetomidine combined with pulmonary protective ventilation against lung injury in patients undergoing surgeries for esophageal cancer with one-lung ventilation (OLV).@*METHODS@#Forty patients with undergoing surgery for esophageal cancer with OLV were randomly divided into pulmonary protective ventilation strategy group (F group) and dexmedetomidine combined with protective ventilation strategy group (DF group; =20). In F group, lung protective ventilation strategy during anesthesia was adopte, and in DF group, the patients received intravenous infusion of dexmedetomidine hydrochloride (0.3 μg · kg ·h) during the surgery starting at 10 min before anesthesia induction in addition to protective ventilation strategy. Brachial artery blood was sampled before ventilation (T), at 30 and 90 min after the start of OLV (T and T, respectively) and at the end of the surgery (T) for analysis of superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), arterial oxygenation pressure (PaO), oxygenation index (OI) and lung compliance (CL).@*RESULTS@#At the time points of T, T and T, SOD level was significantly higher and IL-6 level was significantly lower in the DF group than in F group ( < 0.05). The patients in DF group showed significantly higher PaO, OI and CL index than those in F group at all the 3 time points.@*CONCLUSIONS@#Dexmedetomidine combined with pulmonary protective ventilation strategy can reduce perioperative lung injury in patients undergoing surgery for esophageal cancer with OLV by suppressing inflammation and oxidative stress to improve lung function and reduce adverse effects of the surgery.
Subject(s)
Humans , Analgesics, Non-Narcotic , Pharmacology , Therapeutic Uses , Dexmedetomidine , Pharmacology , Therapeutic Uses , Esophageal Neoplasms , Drug Therapy , General Surgery , Lung , General Surgery , One-Lung Ventilation , Oxidative Stress , Treatment OutcomeABSTRACT
Objective To study and analyze clinical manifestation of depression in comprehensive hospitals in China.Methods Retrospective study was performed.3322 objects included in this research were measured by Minnesota Multiphasic Personality Inventory(MMPI).Results In Chinese comprehensive hospitals,the most common accompanying symptoms of depression were anxiety,fatigue,suicide inclination,apprehension,somatic discomfort,impotence or asexuality,hypochondriasis,somato-complaints,insomnia,self-accusmion and self-reproach,sense of dependence and so on.Depression was positively correlated with suicide risks,self-accusation,delusion of self-accusation,somatic discomfort,somato-complaints,impotence and asexuality,insomnia,headache,fatigue,apprehension,and family problems.Depression had negative correlations with self-strength,social status and economic status.The results had statistical significance.Conclusion Decreased self-strength,increased sense of dependence,low social status and economic status and family problems were the most common pathogenesis basis for depression.Depression can be manifested as various somatic disorders,especially insomnia.