ABSTRACT
Objective To investigate the correlation of blood uric acid in patients with cerebral infarction complicated with hypertention.Methods 68 cerebral infarction patients with hypertention were selected,the other 43 hypertension cases were selected as the contronl group.The uric acid(UA),blood urea nitrogen(BUN),serum creatinine(CRE),glucose(Glu)and total choleststerol(TC),triglyceride(TG),high density lipoproteincholerterol (HDL),low denstiy lipoproteincholerterol(LDL)were compared.Results In the cerebral infarction complicated with hypertention group,the UA,TG,TC and LDL were (397.6 ±89.93)μmol/L,(1.97 ±1.03)mmol/L,(5.92 ± 1.28)mmol/L and (2.92 ±0.85)mmol/L,which were significantly higher than those in the control group[(342.03 ± 107.48)μmol/L,(1.15 ±0.89)mmol/L,(4.53 ±0.75)mmol/L and (2.41 ±0.53)mmol/L,t =8.976,3.015, 4.758,2.986,all P <0.05 ].There was positive correlation between UA and DBP,BUN,TC(r =0.451,0.768, 0.337).Conclusion Hypertension is a risk factor of cerebral infarction,especially in patients with cerebral infarc-tion complicated with hypertension need to detect uric acid,asymptomatic hyperuricemia should be treated actively.
ABSTRACT
@#: Objective To observe the effects of YQHXFF on the expression of matrix metalloproteinase-2 （MMP-2） in the rabbits with hyperlipidemia after percutaneous transluminal coronary angioplasty (PTCA). Methods 28 male New Zealand white rabbits were randomly divided into the control group, the model group and the YQHXFF intervention group. The models of restenosis were established with injuring carotid arteries in cholesterolfied rabbits. After 8 weeks, MMP-2 were measured with reverse transcription polymerize chain reaction (RT-PCR) and pathologic alter were observed with HE staining. Results The expression of MMP-2 mRNA in injured artery were much higher in the model group. Compared with those in the model group, the expression of MMP-2 in the YQHXFF intervention group markedly decreased and intimal hyperplasia markedly lighten. Conclusion YQHXFF can inhibit the expression of MMP-2 and lighten the intimal hyperplasia after PTCA.