ABSTRACT
We report a case of subcutaneous phaeohyphomycosis caused by Exophiala(E,) jeanselmei in a 66-year-old female, who showed a mild tender, 4.5x3.5cm sized, erythematous cystic mass with satellite lesions on the left forearm for 4 months. Histopathologically, suppurative granulomatous inflammation, brownish conidia in a chain and hyphae were observed. Fungal culture grew out the typical black-gray velvety colonies of E. jeanselmei after 2 weeks. The isolate grow well at 25 C, but very poorly at 37 C. No growth could be observed at 40 C. Sporulation adequate for evaluation was present on the malt extract agar. We confirmed E. jeanselmei by colony and microscopic morphology, temperature tolerance and sugar assimilation tests. The patient had been treated with itraconazole for 6 momths. Complete remission was observed.
Subject(s)
Aged , Female , Humans , Agar , Exophiala , Forearm , Hyphae , Inflammation , Itraconazole , Phaeohyphomycosis , Spores, FungalABSTRACT
The characters of modern buildings such as higher airtightness, frequent usage of artificial materials and artificial air conditionings provide suitable conditions for flourishing of microorganisms, especially fungi. Indoor fungi could produce unacceptable musty smells and cause structural damage of building. But the more serious effects are the threatening on human health. They could provoke several allergic diseases, sick building syndrome, organic dust toxic syndrome, and could be the important causative agents of infectious diseases in the immunocompromized host. This paper review the characters, physiology, epidemiology and isolation techniques of the indoor fungi to provide the basic ideas to control the indoor fungi.
Subject(s)
Humans , Air Conditioning , Communicable Diseases , Dust , Epidemiology , Fungi , Physiology , Sick Building Syndrome , SmellABSTRACT
Phaeohyphomycosis refers to subcutaneous and systemic fungal infections characterized by dematiacious septate mycerial elements in tissue, We are discribing the first report of subcutaneous phaeohyphomycosis by Drechslera dematioidea in a 9-year-old boy who presented a slow-growing 4x5.5cm erythematous plaque with somewhat verrucous and eczematous lesion on the dorsal aspect of his right foot after receiving a burn by boiling liquid at 2 years of age. Biopsy of the lesion revealed granulomatous inflammation, brownish spores in chain and planate-deviding sclerotic bodies in the epidermis and upper dermis. Findings by microscopic examination and consecutive cultures of scales and biopsy specimen were consistent with Drechslera dematioidea. The lesion was successfully treated with itraconazole.