ABSTRACT
To determine pre- and postoperative serum S100B concentrations in patients with intracranial tumours that underwent craniotomy and compare the values with healthy controls. An observational, comparative study. Neurosurgical Ward, Jinnah Postgraduate Medical Centre. Karachi, from May 2007 to April 2008. Serum S100B was measured pre- and postoperatively on days 1, 2 and 7 in 18 healthy controls and similar number of patients who underwent craniotomy for intracranial tumours. Mean pre-operative patients and control values were compared using Mann-Whitney [unpaired] or Wilcoxon [paired] tests for comparing between pre- and postoperative values. The p-value was considered significant at < 0.05. Serum S100B concentrations were significantly higher in patients with mean value of 0.19 +/- 0.12 microg/L than in healthy controls [mean 0.03 +/- 0.01, p < 0.0005]. Significantly raised serum S100B concentrations were observed in all postoperative samples when compared with pre-operative samples. S100B concentrations significantly increased on postoperative day 1 [mean = 0.90 +/- 1.07 microg/L, p < 0.0005], decreased on day 2 [mean = 0.84 +/- 0.57 microg/L, p < 0.0005]. The concentrations further declined on day 7 [mean = 0.44 +/- 0.43 pg/L, p = 0.005]. The significantly high postoperative concentrations of S100B in patients appear as a consequence of tissue damage due to surgical procedures. The absence of fall of the S100B concentration in serum from the peak value on postoperative day 1 and day 2 could provide early warning of brain tissue damage leading to neurological deterioration
ABSTRACT
Alteration in platelet morphology and functions are associated with pathological processes and increased risk of vascular complications in patients with diabetes. The purpose of the study was to find the correlation between platelet indices with fasting blood glucose, HbA1c and hs-CRP level in pathogenesis of vascular complications in type 2 diabetic patients. The study has been carried out on 51 Type 2 Diabetics and 55 age and sex matched healthy control subjects. Fasting blood glucose [FBG], Glycosylated hemoglobin [HbA1c], high sensitivity C- reactive protein [hs-CRP] level and platelet indices including Platelet count [PLT], Plateletcrit [PCT], Mean platelet volume [MPV], Platelet distribution width [PDW] were estimated and compared with normal subjects. The results were evaluated statistically. The study demonstrated that FBG, HbA1c, MPV, PDW and hs-CRP were statistically higher in diabetics in comparison with control subjects [P is less than 0.05]. Positive correlation of FBG with HbA1c [r is equal to 0.993, P is equal to 0.0001], PLT with PCT [r is equal to 0.922, P is equal to 0.0001] and MPV with PDW [r is equal to 0.332, P is equal to 0.024] was found in diabetics. The poor glycemic control is positively correlated with high HbA1c level. The increased values of MPV, PDW and elevated hs-CRP level may also serve as confirmatory test in finding risk of developing complications