ABSTRACT
Objective: To evaluate the relation between nephrin levels and preeclampsia severity by comparing serum and urine levels of nephrin in the severe and mild groups according to severity of associated intrauterine growth retardation [IUGR] development
Methods: A total of 150 patients who attended our ante-natal clinic [ANC] were included in this study. We had 5 groups; Group 1:30 patients with mild preeclampsia [MP] and normal fetal development [NFD], Group 2:30 patients with severe preeclampsia [SP] and NFD, Group 3: 30 patients with MP and IUGR, Group 4: 30 patients with SP and IUGR and Group 5: 30 volunteers who were normotensive and non-preeclamptic. We obtained both blood and urine samples for measuring nephrin levels
Results: Both serum and urine nephrin levels were significantly higher for the fourth group compared with all other groups [p<0.001]. The levels of SP group with NFD were measured considerably higher than MP group out of IUGR and control group [p<0.001]. Urine and serum nephrin levels with gestational age of delivery showed a negative correlation [r=-0.621, p<0.001] and also urine and serum nephrin levels with birth weight showed a negative correlation too [r=-0.655 p<0.001]
Conclusion: Both serum and urine nephrin levels correlated with the severity of preeclampsia and IUGR development
ABSTRACT
Objective: There is an increasing rate of ectopic pregnancy with the use of assisted reproductive techniques. There is currently no serum test to differentiate ectopic pregnancy from miscarriage. Early and accurate detection of ectopic pregnancy may prevent the development of complications. The aim of this study was whether the ratio of serum/curettage material hCG could provide us with reliable and early diagnosis in distinguishing miscarriage and ectopic pregnancies and also to measure the diagnostic accuracy rate of this method
Methods: A total of 24 patients were evaluated. Twelve of them were diagnosed as an ectopic pregnancy and 12 of them were diagnosed as a miscarriage. All the patients' diagnoses were confirmed pathologically. Non-of the patient had viable fetus. All participants underwent curettage protocol. Serum and curettage material were obtained at the same time. HCG measurements were done from blood and curettage material
Results: Ratio of Blood/Curettage Material HCG provides fast and reliable results within a few hours with 91.7% accuracy rates
Conclusion: Ratio of blood/curettage material HCG can be used as a reliable method for differentiating ectopic pregnancy and miscarriage