Toxicity of isoniazid [INH]; role of biochemical monitoring tests and history of weakness. the management of pulmonary tuberculosis in placebo controlled study

To compare the untoward effects of isoniazid [inh] and placebo as an anti-tuberculosis therapy in tuberculosis patients. Study Prospective study. Free T.B Clinic, Muhammad Medical College Hospital Mirpurkhas Sindh. Period: June 2007 to Dec 2007. Patients, Method and Patients were selected with filling of consent forms from free T.B Clinic. Prospective study of adverse effects of INH Isoniazid in tuberculosis treatment. It is concluded like other anti-biotics, Isoniazid must be carefully, mentioned in combination therapy of Anti-Tuberculosis Therapy. The major side effects are those giving rise to serious health hazards, require discontinuation of the drug and referral to chest physician