Effect of some opioids on plasma glucose and liver glycogen in STZ-induced diabetic rats

Opioid analgesics are used widely to control various types of pain. Several studies reported that opioid analgesics may produce lowering plasma glucose. The present work aims to investigate the effect of both tramadol and fentanyl on the plasma glucose and liver glycogen of streptozotocin [STZ] induced diabetic rats and declares the possible mechanism of this effect. IV administration of either tramadol or fentanyl for 4 successive days in STZ-induced diabetic rats produced significant reduction in fasting and random plasma glucose in comparison with non-treated STZ-induced diabetic rats. IV Naloxone [mu opioid [MOP] receptor blocker] 30 min. before administration of either tramadol or fentanyl blocked the effect of both tramadol and fentanyl on fasting and random plasma glucose. IV injection of both tramadol and fentanyl in STZ-induced diabetic rats for 4 successive days, produced significant recovery [increase] of glycogen content of the liver in diabetic rats compared with diabetic non-treated group. This effect was also blocked by IV naloxone administration 30 min before administration of either tramadol or fentanyl. The histochemical examination of PAS stained sections of the liver, prepared from rats used during this work, confirmed the results obtained by chemical detection of glycogen content of the liver homogenate. I.V injection of either tramadol or fentanyl produced significant increase in pain tolerance. I.V naloxone 30 min. before adminstration of either tramadol or fentanyl partially blocked the analgesic effect of tramadol, while the analgesic effect of fentanyl was completely blocked. These results suggested that both tramadol and fentanyl have a significant anti-hyperglycemic effect. This effect could be through activation of MOP receptors which may be mediated through increased glycogen deposition in the liver

Comparative evaluation of cytostatic effect of acetyldinaline against bn rat myelocytic leukemia and L 4415 rat lymphocytic leukemia

This work studied the differential efficacy of acetyldinaline [ACD] against L4415 rat leukemia as a relevant preclinical model for human ALL and BNML rat leukemia. ACD was given daily orally in a dose of 11.85 mg/kg b. wt. for one, two or four courses, each course of five consecutive days. In conclusion, ACD had extremely impressive anti- leukemic effect against the BNML rat model, while it had a strong anti-leukemic activity against the L4415 acute lymphocytic evaluation of acetyldinaline in acute lymphocytic leukemia rat model

effects of melatonin administration on some endocrine functions in rats

This study was conducted to investigate the effects of chronic oral melatonin administration in dose of 0.4 mg/kg B.W. daily for 30 days on serum TSH, T4, FSH, LH and insulin. 160 albino rats of both sexes were used, they were grouped into 16 groups, of which 8 groups were used to investigate the endocrinal effects of melatonin in both light and dark conditions. The other 8 groups were used for the same investigations under stressful condition in both light and dark as well. Half of all these groups were served as placebo controls. It was concluded that exogenous melatonin is recommended only as replacement therapy for persons sleeping in light to avoid disturbance of thyroid function especially in hyperthyroid patients. Also, melatonin has no role in counteracting the effects of acute stress on the endocrine functions related to TSH, T4, LH, FSH and insulin