ABSTRACT
Objectives@#To investigate the relationship between subjective sleep quality and cognitive function in patients with subjective memory impairment (SMI), a self-perceived cognitive decline without objective cognitive impairment, and amnestic mild cognitive impairment (aMCI). @*Methods@#We enrolled 246 patients with memory impairment (126 with SMI and 120 with aMCI) who fulfilled the Korean version of the Pittsburgh Sleep Quality Index (PSQI-K), a standardized battery of neuropsychological tests, and mood questionnaires. Based on the PSQI-K cutoff point of 5, patients were classified as good sleepers (GS) or poor sleepers (PS). @*Results@#There was no difference in the proportion of GS and PS between patients with SMI and aMCI [68 PS (54.0%) in SMI vs. 62 PS (51.7%) in aMCI, p>0.05]. Demographics did not differ between the SMI and aMCI groups. In both the SMI and aMCI groups, PS had worse sleep-wake parameters, such as sleep latency, total sleep time, and sleep efficiency, than GS and reported worse performance in all PSQI-K subcomponents. Neuropsychological data were not different between GS and PS, except for the Stroop word test in patients with aMCI. Depressive scores were worse in PS than in GS in both the SMI and aMCI groups. @*Conclusions@#We observed that cognitive function was not significantly different between GS and PS in both the SMI and aMCI groups, except in the Stroop word test in the aMCI group, while PS had more depressive mood than GS in both groups. This suggests that subjective sleep quality may depend on mood disturbances in patients with mild cognitive impairment.
ABSTRACT
Objectives@#To investigate the relationship between subjective sleep quality and cognitive function in patients with subjective memory impairment (SMI), a self-perceived cognitive decline without objective cognitive impairment, and amnestic mild cognitive impairment (aMCI). @*Methods@#We enrolled 246 patients with memory impairment (126 with SMI and 120 with aMCI) who fulfilled the Korean version of the Pittsburgh Sleep Quality Index (PSQI-K), a standardized battery of neuropsychological tests, and mood questionnaires. Based on the PSQI-K cutoff point of 5, patients were classified as good sleepers (GS) or poor sleepers (PS). @*Results@#There was no difference in the proportion of GS and PS between patients with SMI and aMCI [68 PS (54.0%) in SMI vs. 62 PS (51.7%) in aMCI, p>0.05]. Demographics did not differ between the SMI and aMCI groups. In both the SMI and aMCI groups, PS had worse sleep-wake parameters, such as sleep latency, total sleep time, and sleep efficiency, than GS and reported worse performance in all PSQI-K subcomponents. Neuropsychological data were not different between GS and PS, except for the Stroop word test in patients with aMCI. Depressive scores were worse in PS than in GS in both the SMI and aMCI groups. @*Conclusions@#We observed that cognitive function was not significantly different between GS and PS in both the SMI and aMCI groups, except in the Stroop word test in the aMCI group, while PS had more depressive mood than GS in both groups. This suggests that subjective sleep quality may depend on mood disturbances in patients with mild cognitive impairment.
ABSTRACT
OBJECTIVE: Cognitive impairment is one of the nonmotor symptoms in Parkinson's disease (PD), and olfactory dysfunction is used as a marker to detect premotor stages of PD. Serum uric acid (sUA) levels have been found to be a risk factor for PD. Our objective in this study was to examine whether sUA levels are associated with cognitive changes and olfactory dysfunction in early de novo PD patients. METHODS: The study participants included 196 de novo PD patients. We assessed cognitive function by the Korean versions of the Mini-Mental State Examination and the Montreal Cognitive Assessment and assessed olfactory function by the Korean version of the Sniffin' Sticks test. RESULTS: The mean sUA level was 4.7 mg/dL and was significantly lower in women than in men. Cognitive scores were lower in women, suggesting that sUA levels were related to cognitive function. The olfactory functions were not related to sUA level but were clearly associated with cognitive scores. Olfactory threshold, odor discrimination, and odor identification were all significantly related to cognitive scores. CONCLUSIONS: We conclude that lower sUA levels were associated with cognitive impairment, not olfactory dysfunction, in de novo PD patients. This finding suggests that UA is neuroprotective as an antioxidant in the cognitive function of PD patients.
Subject(s)
Female , Humans , Male , Cognition Disorders , Cognition , Discrimination, Psychological , Odorants , Parkinson Disease , Risk Factors , Smell , Uric AcidABSTRACT
Internal jugular vein (IJV) thrombosis is a form of deep vein thrombosis that has a potentially fatal outcome associated with its intracranial propagation. Computed tomography and ultrasonography are useful diagnostic tools. We report a case of IJV thrombosis associated with lymphoma that was detected by carotid ultrasonography and had disappeared in follow up ultrasonography.