ABSTRACT
The genetically determined ability to metabolize debrisoquine(DBR) is related to risk of lung cancer and DBR hydroxylation exhibits wide inter-individual variation. In this study, 100 korean adults were tested for their ability to metabolize DBR. The DBR metabolic phonotype were determined by metabolic ratio (MR, DBR/4-HDBR) which is the percent dose excreted as unchanged DBR divided by the percent dose excreted as 4-hydro-xydebrisoqinne(4-HriBR) in a aliquots of an eight hour urine sample, after 10 mg DBR test dose administration. Analysis was performed on a capillary gas chromatography fitted with electron capture detector. The results were as follows; 1. Geometric mean or DBR MR was 0.32 in male, 0.27 in female, 0.30 in total and the distribution of log(MR) was seemed to follow normal distribution. 2. Metabolic ratio of DBR was higher in non-smoker and non-drinker than in smoker and drinker without any statistically significant difference. 3. None of personal factors was significantly related to DBR MR except age. 4. The DBR metabolic phonotype was extensive metabolizer(EM) 93, intermediate metabolizer (IM) 7 by traditional method and EM 98, IM 3 by Caporaso's method. The poor metabolizer (PM) phenotype was not found by either method. 5. Maximal expected PM phenotype was 0.36% by traditional method and 0.04% by Caporaso's method.
Subject(s)
Adult , Female , Humans , Male , Capillaries , Chromatography, Gas , Debrisoquin , Hydroxylation , Lung Neoplasms , Metabolism , Pharmacogenetics , PhenotypeABSTRACT
Phenol sympathetic block is valuable for the treatment of ischemic pain, gangrene, intermittent claudication, Pager's disease of the bone and pain associated with pancreatitis, pancreatic cacinoma, etc. The author has experienced a case of successful lumber sympathetic block using 7% phenol under fluroscopy and given to a patient with Buerger's disease who had severe pain and ulceration of the right great toe for several years. After the sympathetic block, 2 epidural blocks with 2.5% bupivacaine were done in order to augment the effects of this sympathetic block. Subsidence of rest pain, increase in walking distance from under 100M to over 500M and circulatory improvement of the affected limb were observed. Imporvement of circulation was confirmed by strain gauge plethysomgraphy.
Subject(s)
Humans , Bupivacaine , Extremities , Gangrene , Intermittent Claudication , Pancreatitis , Phenol , Thromboangiitis Obliterans , Toes , Ulcer , WalkingABSTRACT
It is well known that small dose of belladonna alkaloid(atropine, scopolarnine) has the effect of decreasing the heart rate in normal conscious subjects, but the mechanism involved in it remains still unanswered. Based on various lines of evidence, the most likely mechanism seems to be the blockade of sympathetic ganglion caused by the alkaloids and it is possible that the effect on the slower heart rate may differ in the depressed state of the sympathetic ganglion when under halothane anesthesia. The present study was undertaken, therefore, on comatose patients and halothane anesthetized patients with and without atropine premedication about 1 hour before anesthesia to observe the effect of a small dose of scopolamine(0.1 mg) which affects the heart rate more significantly than atropine in conscious subjects. The results were as follows: 1) In the comatose patients, scopolamine(0.1 mg) produced a significant decrease in heart rate. 2) During halothane anesthesia without atropine premedication, scopolamine produced a slight decrease in heart rate. 3) During halothane anesthesia with atropine premedication, scopolamine produced a significant increase in the heart rate. These results indicate that scopolamine can further affect the sympathetic ganglion already depressed by halothane, and it is suggested that scopolamine is more effective in blocking the sympathetic ganglion than halothane.