ABSTRACT
PURPOSE: Both benign prostate hyperplasia(BPH) and male pattern baldness (androgenic alopecia) share the pathogenesis of androgen dependent disorder in addition to afflict large population of old men with chronobiological progress. However, it is unclear that both diseases relate to each other on epidemiologic basis. We evaluated the frequency and severity of male pattern baldness between the patients with BPH and control group. MATERIALS AND METHODS: A total of 225 patients with BPH(mean age: 69.3+/-6.5years) and 160 controls(mean age: 68.5+/-6.4 years), whose age over 60, was included in this study. The estimation of bladness severity was based on the Norwood's classification(grade 1 to VII). International prostate symptom score (IPSS) and genetic tendency of baldness were also evaluated. The difference of IPSS and grade of baldness between two groups were analysed by Mann-whitney test and the frequency of inherited baldness were compared by Chisquare test. Correlations between severity of baldness and IPSS of each group were estimated by Spearman's rank correlation method. RESULTS: It was noted that the patients with BPH had an apparent higher grade of male pattern baldness in comparison with that of controls(median value of IV to 111, p<0.001). The proportion of male pattern baldness with grade IV or greater in BPH group was significantly larger than that of controls(53.8% versus 36.9%, p<0.01). There was greater frequency of inheritant baldness in BPH group than in controls(31.6% versus 12.5%, p<0.001). No significant correlations were noted between baldness severity and IPSS in both groups. CONCLUSIONS: Our study demonstrated there was a strong association of BPH with male pattern baldness.
Subject(s)
Humans , Male , Alopecia , Hyperplasia , ProstateABSTRACT
PURPOSE: The efficacy of continuous bladder irrigation with amphotericin B versus oral administration of fluconazole(Diflucan ) was compared in the treatment of patients with candiduria. . MATERIALS AND METHODS: A prospective and comparative study of candiduriawas done on 28 patients(Amphotericin B: 13, Fluconazole: 15). Continuous bladder irrigation with 50mg amphotericin B/iota sterile water infused during 24 hours for 2 days was compared to oral administration of 50-100mg/day fluconazole for a range of 7-14 days. Urine culture were obtained 3days, 7 days after continuous bladder irrigation with amphotericin B and 7 days, 14 days after oral administration of fluconazole. RESULTS: The organism was eradicated in 10 patients(76.9%) who received continuous irrigation of amphotericin B and 11 patients(73.3%) who received oral fluconazole therapy. So, There was no statistically significant difference between continuous bladder irrigation with Amphotericin B group and oral medication of fluconazole group(p>0.05). CONCLUSIONS: There was no difference in the cure rate of candiduria between continuous bladder irrigation with Amphotericin B group and oral medication of fluconazole group. So, patient's condition(Foley catheterization, possibility of ambulation and oral feeding) and convinience will be the important deciding factors to select adequate treatment method of candiduria.