ABSTRACT
Twin-to-twin transfusion syndrome (TTTS) is one of the complications showing high mortality rate in monochorionic twins with vascular communication in the placenta. Clinical manifestations of TTTS are usually characterized by polyhydramnios, circulatory overload, cardiac failure and fetal hydrops in the recipient twin and symmetrical fetal growth restriction, oligohydramnios, hypovolemia and anemia in the donor twin. TTTS occurres in 10-35% of monochorionic twins. We report three cases of TTTS with fetal hydrops in which amnioreduction was serially attempted and maternal digoxin treatment was tried for the therapeutic purpose.
Subject(s)
Female , Humans , Pregnancy , Anemia , Digoxin , Fetal Development , Fetal Therapies , Fetofetal Transfusion , Heart Failure , Hydrops Fetalis , Hypovolemia , Mortality , Oligohydramnios , Placenta , Polyhydramnios , Tissue DonorsABSTRACT
OBJECTIVE: To understand the pathogenesis of adenomyosis through the immunohistochemical staining with bcl-2 and matrix metalloproteinase-9 (MMP-9) antibody. METHODS: We selected 45 cases of adenomyosis among the uterine specimens that were extirpated surgically due to benign gynecologic problem. Immunohistochemical staining to the myometrial tissue was performed using anti-bcl-2 and anti-MMP-9 antibodies. Staining was qualitatively assessed in terms of extent and intensity. RESULTS: There were 32 cases of proliferative phase and 13 cases of secretory phase depending on the date of endometrium. Anti-bcl-2 stained 81.3% (26/32) compared with anti-MMP-9 stained 6.3% (2/32) in the glandular tissue of the proliferative phase (p<.001). In the secretory phase, anti-bcl-2 92.3% (12/13) and anti- MMP-9 7.7% (1/13) respectively (p<.001). In the stromal tissue of the proliferative phase, anti-bcl-2 stained 62.5% (20/32) compared with anti- MMP-9 stained 6.3% (2/32) (p<.001). In the secetory phase, anti-bcl-2 84.6% (11/13) and anti-MMP-9 15.4% (2/13) (p<.001). CONCLUSION: The adenomyosis may be developed from simple invagination and cellular proliferation of endometrial tissue, not caused by myometrial infiltration of endometrial tissue.
Subject(s)
Female , Adenomyosis , Antibodies , Cell Proliferation , Endometrium , Matrix Metalloproteinase 9ABSTRACT
A balanced insertion of a parent may produce normal or carrier offsprings, spontaneous abortions, and chromosomally unbalanced offsprings. This is a rare report of duplication of chromosome 10q22->q24 which has arisen through the segregation of a balanced direct insertion. The partial trisomy 10q is a specific syndrome of mental retardation and malformation characterized by psychomotor delay, growth restriction, distinctive dysmorphic appearances, and, in some cases, cardiac, renal, and ocular abnormalities. We have experienced a case of partial trisomy 10q from maternal balanced insertion, which was prenatally showed severe fetal growth restriction and oligohydramnios, and present it with a brief review of literatures.
Subject(s)
Female , Humans , Pregnancy , Abortion, Spontaneous , Fetal Development , Intellectual Disability , Oligohydramnios , Parents , TrisomyABSTRACT
Vulvar glassy cell carcinoma (GCC) is a very rare neoplasm. Although GCC is considered to be a poorly differentiated variant of adenosquamous carcinoma, its real nature is still debatable. We report a case of GCC of the vulva in a 53-year-old woman and review the literatures. The patient had bleeding from the lesion of the vulva and pelvic MRI revealed left inguinal lymph node enlargement. Histologically a cytoplasm of ground glass appearance was observed with a distinct cell wall and large nucleus containing prominent nucleoli. The clinical stage of the tumor was III as classified by the International Federation of Gynecology and Obstetrics (FIGO). She was treated by a left hemivulvectomy and bilateral inguinal lymphadenectomy and followed by external irradiation to the pelvis and left inguinal area. The patient was still alive without evidence of disease after 12 months treatment.