ABSTRACT
OBJECTIVES: To examine the associations between the urinary t, t-muconic acid (t, t-MA) concentration and three indices of insulin resistance; namely, the homeostasis assessment of insulin resistance (HOMA-IR) index, blood insulin level and fasting glucose level. METHODS: A panel study was performed on the elderly at a public health care center population in the northern area of Seoul between 2008 and 2010. The participants were 560 elderly, over 60 years of age whose urinary t, t-MA and insulin resistance indices had been measured; questionnaires were completed by these participants. A generalized linear mixed (GLM) analysis was adjusted for age, sex, drinking, urinary cotinine, exercise, vitamin intake and body mass index, at a significance level of p<0.05. RESULTS: A total of 411 participants were finally analyzed after excluding those with diabetes and only one visit to the public health care center. Higher urinary t, t-MA concentrations were linearly associated with the HOMA-IR index, blood insulin level and fasting glucose level in the simple and fully adjusted GLM models. Although there were few limitations, a portion of insulin resistance was proven to be explained by exposure to benzene using r-squared. A significant relationship was also observed between urinary t, t-MA and malondialdehyde (MDA) using the same GLM models. CONCLUSIONS: Urinary t, t-MA is related to the development of insulin resistance which is a key factor for development of diabetes and its complications induced by oxidative stress.
Subject(s)
Aged , Humans , Benzene , Body Mass Index , Cotinine , Drinking , Fasting , Glucose , Homeostasis , Insulin , Insulin Resistance , Malondialdehyde , Oxidative Stress , Public Health , Surveys and Questionnaires , VitaminsABSTRACT
OBJECTIVE: To evaluate the changes in respiratory function associated with daily changes in particulate pollution. METHODS: A total of 105 healthy schoolchildren of fourth and fifth grade elementary school age performed peak expiratory flow rates (PEFR) during 2 periods (May 14~June 15, Oct 22~Nov 23). We monitored concomitant ambient particulate matter (PM) levels during the periods. RESULTS: An elevation PM(10) level of 1 microgram/m) led to decreases in PEFR of 0.20 L/min. A 1 microgram/m3 elevation of PM(2.5) led to a decrease of 0.36 L/min in PEFR. In addition, 1 day lag was associated with PM(10) levels and PEFR changes, and PM(2.5) showed the same result. The metal levels determined at PM(10) and PM(2.5) were found to be associated with decreased respiratory function. CONCLUSIONS: An association between respiratory function and particulate pollution was observed when particulate pollutant levels were lower than the yearly average National Ambient Air Quality Standard in the Korea(50 microgram/m3).
Subject(s)
Child , Humans , Metals , Particulate Matter , Peak Expiratory Flow Rate , Respiratory Function TestsABSTRACT
No abstract available.
Subject(s)
Animals , Humans , Male , Babesiosis , Clindamycin , QuinineABSTRACT
No abstract available.