ABSTRACT
Encephalomyelopathy is a rare complication of chemotherapy and radiotherapy , and it is a serious cause of morbidity and mortality in the children with Acute Lymphoblastic Leukemia (ALL). A fifteen years old girl, who was diagnosed with ALL 3 years ago, developed CNS relapse 2 years after diagnosis and undertook CNS relapse protocol ( 2400 cGy cranial + 1500 cGy spinal radiotherapy, meanwhile intrathecal chemotherapy with MTX + ARA-C + Prednisone 5 times). Eight months later from radiotherapy, firstly right hemiparesy consequently quadriplegia and quadriparestesia developed, stool and urine incontinence occured, respiration problems started and progressively increased, so she exitus due to respiration deficiency.
ABSTRACT
Hypercalciuria is of continuing interest as a risk factor for kidney stones in children. We screened 592 healthy Turkish children (308 boys, 284 girls, aged 3 month-16 years) for hypercalciuria by measurement of urinary calcium/creatinine (UCa/Cr) ratio in the second-morning urine samples. Hypercalciuria was noted in 17 children (2.9%), 9 of them were boy and 8 of them were girl. Oral calcium-loading test could only be done in 7 children who were diagnosed as having hypercalciuria, and it revealed absorptive hypercalciuria in 2 cases and renal hypercalciuria in no cases. The frequency of a family history of urolithiasis in asymptomatic hypercalciuric children was 50%. Median UCa/Cr ratios and urinary magnesium/creatinine (UMg/Cr) ratios were 0.11 and 0.10 and the 97th percentiles were 0.32 and 0.23 respectively. The UCa/Cr ratio in second-morning urine samples was correlated with the UMg/Cr ratio (r = 0.44) and was independent of age and sex.