Evaluating success of no-scalpel vasectomy by ligation and excision with fascial interposition in a large prospective study in Islamic Republic of Iran

The aims of this prospective, non-comparative study were to determine time to azoospermia and vasectomy success rate based on the results of semen analysis. A total of 334 men seeking vasectomy at a clinic in Urmia city, Islamic Republic of Iran were followed bi-weekly up to 24 weeks after vasectomy or until azoospermia was confirmed via semen analysis. The cumulative life table rate for azoospermia was 93/100 men [95% Cl: 88.1 to 97.9]. The median time to azoospermia was 10 weeks. By week 24 of follow-up, 3.3% of participants had failed to achieve azoospermia. One pregnancy was reported during the study period and attributed to user failure. The results suggest that men can begin to rely on vasectomy for contraception 12 weeks after no-scalpel vasectomy using fascial interposition performed by an experienced surgeon

[ frequency of M34T, 167delT, 235delC and 35delG mutations in GJB2 gene in autosomal recessive non-syndromic hearing loss patients in west Azarbaijan]

Mutations in GJB2 gene is the most common cause of autosomal recessive nonsyndromic hearing loss in many populations. The aim of this study was to determine the frequency of 35delG, 167delT, M34T, 235delC mutations in West Azarbaijan population. 129 patients from 96 families were studied. Mutations were detected using ASOPCR and PCR-RFLP methods. Totally, 65.89% of cases were sporadic and the remaining [34.11%] were familial. Six out of 8 cases with 35delG mutation and one case with 235delC mutation were offspring of consanguineous union. Mutations of 35delG were detected in 8 families. 167delT and M34T mutations were not found but 235delC was detected only in one family. On the other hand, 13 out of 258 chromosomes had 35delG mutations. Five patients were homozygous and 3 were heterozygous for 35delG mutation. It means that, in 5.04% of the patients the major reason for hearing loss was 35delG mutation. One out of 258 [0.39%] chromosomes had heterozygous 235delC mutation. It can be concluded that the other genes or mutations could result in autosomal recessive nonsyndromic hearing loss in West Azerbaijani population