ABSTRACT
This study comprised 60 patients with ulcer and non ulcer lesions and 20 persons as a control group, with age ranging from 16-66 years. Three biopsies were taken from stomach, antrum and duodenum for pathological studies and radio- immunoassay detection of serum pepsinogens level. The results of this study showed increased level of serum PGI and high PGI/PGII ratio in cases with duodenal ulcers and duodenitis than those of control group, gastric ulcer patients and patients with gastritis. Also we found that elevated serum level of PGII with decreased PGI/PGII ratio in cases of gastric ulcer and patients with gastritis than those of control group, duodenal ulcer patients, patients with non ulcer lesions as patients with duodenitis and gastro duodenitis. Radio immunoassay of serum pepsinogens I and II are considered as a good markers for detection of early gastro duodenal lesions and they are markedly changed in established cases with duodenal or gastric ulcers