[Wolfram syndrome about 2 family cases]

Wolfram syndrome or DIDMOAD syndrome is an hereditary optic atrophy occurring in insulin-dependent diabetics. It can be associated with other endocrinal, ORL, neurologic or urologic disorders, We report 2 cases: brother and sister presenting 2 principal signs of this syndrome: optic atrophy and insulin-dependent diabetes. The ophthalmologic exam shows a visual acuity at stade of blindness. The genetic inquiry shows a parental consanguinity and 2 other supposed dead cases affected in the family

New treatments of premacular hemorrhages - about 5 cases

To evaluate functional results and evolution of premacular hemorrhages treated with Nd Yag laser. 5 patients presenting a macular hemorrhage were treated with Nd Yag laser. The cause was ruptured macroaneurysm in 2 cases, diabetic retinopathy in 2 cases, Valsalva manoeuvre in one case. Minimum number of impacts and minimal power are underwent to permit through a hyaloidotomy to the blood to flow out in the vitreous cavity. Surveillance comported visual acuity measurement and ophthalmoscopy. The follow up is 4 months. Initial visual acuity was limited to light perception. Ophthalmoscopy showed in all cases premacular hemorrhage of great size: [5 at 7 papillary diameters] and hemorrhage's etiology in 4 cases. Visual acuity improvement was noted in 4 cases with mean visual acuity of 5/10 after treatment [4/10 at 7/10]. Treatment of premacular hemorrhages with laser Nd Yag have the advantage to permit rapid resolution of hemorrhage and to restore visual acuity in young patients in activity. premacular hemorrages treatment with Nd Yag laser is a non invasive technique efficient and safe