ABSTRACT
The current study has been designed to compare the diagnostic value of pipelle sampling as a simple and cost effective method with that of more complicated and expensive methods in the detection of pathologies in abnormal uterine bleedings. In 60 patients scheduled for hysterectomy due to persistent uterine bleeding, endometrial sampling was done twice, once with pipelle and then by D and C prior to the hysterectomy. First the pathological reports of pipelle and D and C specimens were compared with each other and then both were compared with hysterectomy as the gold standard. In all cases pipelle was passed to the uterine cavity without any need for cervical dilatation and anesthesia. The most frequent results in all tree kinds of sampling were proliferate endometrium and early secretary phase respectively. According to the pathological reports, pipelle and D and C in 89% of the cases, pipelle and hysterectomy in 80% of the cases and D and C and hysterectomy in 90% of the cases showed agreement, that shows so significant difference in diagnostic accuracy among three methods. Considering high agreement between pathological reports of pipelle biopsy as an outpatient method and those of D and C and hysterectomy, pipelle sampling is suggested as the first diagnostic procedure, while D and C and hysterectomy that necessitate anesthesia and take more time and expense should be reserved for just special cases