Urinary pyrilinks-D / creatinine ratio and serum estradiol levels in long-term deport medroxy progesterone acetate users

This study was done on 36 women who had been using depot medroxy progesterone acetate [DMPA] for more than three years [as cases] by injection of 150 mg/3 months and on 12 women who had never used it before [as control]. Urinary pyrilinks-D/creatinine ratios [nM/mM] and serum estradiol level [pg/ml] were assessed. Women who had been using DMPA showed significantly higher urinary pyrilinks-D/creatinine ratios and lower serum estradiol levels indicating tendency for higher bone resorption regardless age, parity, weight and height