Biochemcial studies on Alitame, a dipeptide non-nutritive sweetner on healthy and diabetic rats compared to aspartame

In this study, different biochemical parameters were investigated in 90 albino adult rats, Sprague-Dawely strain, divided into two groups [healthy and diabetic]. They were supplied with alitame and aspartame at 10, 50 and 100 mg/kg body weight/day for five weeks. No significant changes were reported in both groups in serum glucose, hemoglobin, total protein, albumin, globulin, A/G ratio and lipid pattern of healthy rats treated with alitame or aspartame at levels of 10 and 50 m/gkg body weight/day. However, a significant elevation was reported in serum glucose, total protein, globulin and A/G ratio at 100 mg/kg body weight/day for both sweeteners in healthy rats. Glucose was significantly decreased in diabetic rats fed alitame when compared with their corresponding control groups. Regarding liver enzymes, both sweeteners significantly elevated aspartate transaminase [AST] levels in healthy and diabetic groups. Alanine transaminase [ALT] and alkaline phosphatase [ALP] levels also increased in aspartame fed diabetic group. There were no statistical differences between the effect of alitame or aspartame on the biochemical aspects of healthy and diabetic rats except for liver enzymes level

Pituitary-gonadal hormones in insulin-dependent and non-insulin dependent diabetic Egyptian males with and without neuropathy or retinopathy

Few prospective data are available regarding the association of pituitary-gonadal hormones, and the risk of developing diabetes mellitus. Therefore, FSH, LH and prolactin were determined in types I and II diabetic male Egyptian patients with and without complications [neuropathy or retinopathy] and nondiabetic healthy controls, testosterone was also assessed. All patients and controls underwent laboratory investigations, including fasting and post-prandial blood sugar level, serum levels of cholesterol, triacylglycerol, HDL-C and LDL-C