Serum selenium status of HIV-infected children on care and treatment in Enugu, Nigeria

Objective. To compare the selenium status of HIV-infected and HIV-uninfected children. Methods. This was a hospital-based comparative study using a structured questionnaire in the quantitative research domain at the University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria. Seventy-four HIV-infected children were compared with 74 non-HIV-infected children (35 males and 39 females in each group). The outcome measure was the selenium status of the study participants. Results. The mean (standard deviation (SD)) weight-for-height z-score among the subjects was ­0.18 (1.53) compared with 0.05 (1.68) among the controls (p=0.457). The mean (SD) height-for-age z-score among the subjects was ­1.16 (1.44) compared with 0.06 (1.06) among the controls (p<0.001). Eighteen subjects (24.3%) compared with eight controls (11.4%) were selenium deficient (odds ratio 2.49; 95% confidence interval 1.00 - 6.18; p=0.044). Median CD4 counts of selenium-deficient and non-deficient subjects were 765.5 (range 409 - 1 489) and 694.0 (range 85 - 2 196) cells/µL, respectively (p=0.321). The proportions of selenium deficiency were 26.4% and 22.2% in the highly active antiretroviral therapy (HAART) and pre-HAART groups, respectively (p=0.565). Conclusion. There was a significant difference in the proportion of HIV-infected children who were selenium deficient compared with their uninfected counterparts

Prevalence and Risk Factors of Anaemia in Paediatric Patients in South-East Nigeria

Background. The causes of anaemia have regional variations; and further variation is expected among paediatric hospital patients. However; the prevalence of anaemia and its contributing risk factors among paediatric patients remain understudied in South-East Nigeria.Methods. The study involved 286 anaemic (haemoglobin (Hb) ?10 g/dL) and 295 non-anaemic preschool children attending a hospital outpatient department. A clinical research form was used to document demographic data; anthropometric measurements; disease details and packed cell volume. Common anaemia risk factors previously documented were studied. The prevalence rates of the independent variables were calculated and level of significance was determined; using ?2.Results. The prevalence of anaemia was 49.2; with the highest prevalence among children 12 months old (p

Non-Traumatic Childhood Coma in Ebonyi State University Teaching Hospital; Abakaliki; South Eastern Nigeria

Background: Coma is a medical emergency; and optimal management; especially in a resource-poor setting; would depend on the knowledge of its etiology and predictors of outcome. This communication reviews the etiology and outcome of non-traumatic childhood coma in Ebonyi State University Teaching Hospital (EBSUTH); Abakaliki. Objective: To determine the incidence; etiology and outcome of non-traumatic coma in children seen at the EBSUTH; Abakaliki. Materials and Methods: This is a retrospective analysis of records of all children admitted to the children emergency ward of EBSUTH in coma of a non-traumatic origin between 1 st of January and 31 st of December; 2007. Results: Forty children presented with coma out of 673 children admitted during the study period; giving an incidence rate of 5.9. The majority of the children (62.5) were aged between 1 and 5 years of age; and 79.5of them were deeply comatose on admission. Most of the cases (85) of non-traumatic coma were due to infective causes; mainly cerebral malaria (47.5); pyogenic meningitis (17.5) and septicemia (10). Twenty-four (60) children recovered while 13 (32.5) died. Conclusion : Infections were the predominant causes of non-traumatic coma in EBSUTH. In view of the high mortality among this group of patients; efforts at the control of malaria and other infections would significantly reduce the incidence of non-traumatic coma in this study site

Some Behavioural Risk Factors for Intestinal Helminthiasis in Nursery and Primary School Children in Enugu; South Eastern Nigeria

The objective of this study was to determine some common behavioural risk factors for intestinal helminthiasis in nursery and primary school children in Enugu. Design: A cross-sectional survey on 460 children attending nursery and primary schools in Enugu was carried out in 2003 with a view to determine some behavioural risk factors for intestinal helminthiasis. Setting: This study was carried out in the research laboratory of the Federal Ministry of Health; National Arbovirus and Vector Research Centre; Enugu. Method: Intestinal helminthiasis was diagnosed using the kato-katz method in analysing fresh stool samples collected from nursery and primary school children in Enugu. These fresh stool samples were collected into appropriately labeled clean containers. Questionnaires were administered by the researchers to obtain data from the children and their parents or guardians as regards some behavioural risk factors for intestinal helminthiasis . Results: The results from this study showed that the prevalence of intestinal helminthiasis was significantly affected by various behavioural risk factors. The rate of helminthic infection varied significantly with hand washing habits after defeacation (X2 = 75.77; df = 2; p = 0.001) and with different habits of washing fruits before eating ( X2 = 52.79; df = 2; p = 0.001) among the pupils. Also; the rate of helminthic infection varied significantly with the source of drinking water (X2 = 55.12; df = 3; p = 0.01); water boiling habits (X2 = 40.89; df = 2; p = 0.001); use of footwear after school hours (X2 = 30.72; df = 2; p = 0.001). Sites utilized for defeacation by the pupils (X2 = 80.25; df = 3; p = 0.001) also significantly influenced the rate of helminthic infection. Conclusion: Various behavioural factors which significantly affect the rate of helminthic infection abound in children living in Enugu. The government should give attention to the control of these behavioural risk factors. A lot of health education will be needed to curb the poor personal hygienic habits which are obvious risk factors for intestinal helminthiasis

Sociodemographic Differences in the Distribution of Hepatitis C Virus Antibodies among Children with Sickle Cell Anemia in Enugu; South East Nigeria

Background:Hepatitis C virus (HCV) has become an important cause of chronic liver disease and liver cancer worldwide. A study of the sociodemographic differences in the distribution of HCV antibodies (Anti-HCV) among those at risk will broaden knowledge of the problem among patients in this part of the country. Objective: To determine the sociodemographic differences in the distribution of HCV antibodies among transfused children with sickle cell anaemia (SCA) in Enugu and compare it with their non- transfused counterparts. Methodology: The study was conducted among two hundred and sixty-nine children with SCA attending the paediatrics sickle cell clinic at University of Nigeria Teaching Hospital (UNTH) Enugu; 136 transfused SCA patients as subjects and 133 age and sex matched non-transfused SCA as controls were studied. Results: There was no statistically significant difference in the age and sex distribution of the anti-HCV positive subjects and controls P 0.05. Majority of the subjects (66.7) and control (71.4) who tested positive were in lower socio-economic class. Conclusion: HCV infection is not uncommon in children with SCA. There is no significant difference in the sociodemographic characteristics of the HCV positive subjects and controls

Effect of Social Class and Area of Domicile on the Prevalence of Intestinal Helminthiasis in Nursery and Primary School Children in Enugu

Objective:The primary objective of the study was to determine the effect of social class and area of domicile on the prevalence of helminthiasis in nursery and primary school children in Enugu.Subjects and method: This was a cross-sectional study in which stool samples were obtained from 460 nursery and primary school children from different social classes and different areas of domicile and analysed for intestinal helminthiasis using the Kato Katz method.Results: One hundred and sixty-six (36.1) of the 460 children studied lived in the urban area; 215 (46.7) lived in the semi-urban area and 79 (17.2) lived in the urban slum area. The prevalence of intestinal helminthic infection was lowest in children living in urban areas (10.2) and highest in those in urban slums (48.4). There was a significant relationship between residential abode or area of domicile and prevalence of helminthic infection (?2 = 59.54; df = 2; p = 0.001).The prevalence of intestinal helminthic infection was highest in the lower class (50.9); lowest in the upper class (9.7) and intermediate in the middle class (21.7). This trend was statistically significant (?2 = 65.06; df = 2; p = 0.001). Conclusion: It is concluded that the prevalence of intestinal helminthiasis is affected by both areas of domicile and social class of children. Hence; intervention by the government to create better areas of domicile and to improve the social class of its populace will reduce the prevalence of intestinal helminthiasis

Experiences; attitudes and beliefs of secondary school students about breastfeeding

The experiences; knowledge; attitudes and beliefs of 824 teenagers from 18 secondary schools in Enugu and Port Harcourt; about infant feeding and in particular breastfeeding; were investigated; using a questionnaire. The students had good experience of both breast and bottle-feeding as over 75 percent of them had been breast and/or bottle fed and over 80 percent had bottle-fed younger children. The students' knowledge of breastfeeding; breast milk and weaning was poor. Despite their extensive experience with bottle feeding and their poor knowledge of breast milk and breastfeeding; the basic attitudes and beliefs of the students about breastfeeding were positive. To reinforce these positive attitudes and beliefs; it is suggested that formal education on breastfeeding and infant feeding be part of health education programmes in secondary schools. By this means; the breastfeeding culture inherent in the community can be promoted and protected

Quintuplet pregnancy. [case report]

A 32 year-old nigerian woman who was admitted with premature rupture of the fetal membranes in the thirty-fifth week of her quintuplet pregnancy is presented. Management is discussed