ABSTRACT
Objective: To evaluate the relationship between estrogen and progesterone receptor status and the presence of diabetes mellitus, hypertension, obesity or dyslipidemia Design: Retrospective study Setting: Department of Oncology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Subjects: A hundred and twelve Saudi patients diagnosed with breast cancer, admitted to King Khalid University Hospital [KKUH] between 2000 and 2006 Intervention: Fine needle or true cut biopsy Main outcome measure: Association between tumor receptor status and the presence of comorbidity
Results: There was no relationship between estrogen receptors and progesterone receptors expression and the presence of diabetes mellitus, dyslipidemia, hypertension or obesity. Hypertension was associated with HER2/neu positivity [p = 0.045, OR = 2.817, CI 95% [1.023 - 7.754]]. Hypertensive patients were also found to present with earlier clinical T-stages [p = 0.045]
Conclusion: Expression of estrogen and progesterone receptors was not affected by the presence of diabetes mellitus, dyslipidemia, hypertension or obesity. However, our findings suggest that hypertension is related to HER2/neu positivity. Hypertensives were also more likely to present with earlier clinical T stages than nonhypertensives