ABSTRACT
Hepatitis C Virus [HCV] is one of the Hepatitis agents known to be transmitted through blood and blood products. Hepatitis C virus has been implicated as a major cause of chronic liver disease and hepatocellular carcinoma worldwide. This study was, therefore, undertaken with the objective of determining the sero-prevalence of HCV Antibodies among blood donors in Prince Hashem Hospital, Zarka - Jordan. A total of blood donors all subjects were tested for Hepatitis C virus antibodies using third generation Enzyme Linked Immunosorbent Assay [ELISA]. In a three year study, eight thousand seven hundred and fifty healthy blood donors in Zarka were screened for anti hepatitis C Virus [anti HCV].The results showed that the prevalence of anti HCV in all donors was 0.79% [0.80% for males and 0.54% for females]. Anti HCV showed prevalence increase with age with a peak of 1.62% in the earlier age group [31 -40 years]. The seroprevalence of blood donor tests were found to be concordant with previous studies held in Jordan [22,23]. Healthy donor selection is of paramount importance in blood bank services. Vigilant donor selection and younger age group affect frequency of HCV. All blood donors must be screened for anti HCV Ab